化浊解毒清幽方加减治疗幽门螺杆菌相关性胃炎临床观察

摘要

[目的]观察基于“浊毒致病学说”所组方剂化浊解毒清幽方对幽门螺杆菌相关性胃炎(HPAG)患者的临床症状、胃镜下表现和幽门螺杆菌(HP)等的影响,寻求治疗HPAG有效的中医药基本方.[方法]采用随机双盲法将64例患者随机分为治疗组和对照组各32例.治疗组给予化浊解毒清幽方(蒲公英、白花蛇舌草、半枝莲、黄连、厚朴、枳实、白芍、木香、延胡索、三七、甘草)加减口服治疗,对照组给予“三联疗法”(雷贝拉唑胶囊+阿莫西林胶囊+甲硝唑片)治疗.对2组治疗前后的一般情况、胃镜下改变及根除HP情况等进行观察分析.[结果]治疗后,治疗组的临床症状疗效和胃镜疗效显著优于对照组,差异均有统计学意义(P＜0.05)；2组的抗HP感染疗效比较,差异无统计学意义(P＞0.05),表明2组的抗HP感染疗效相仿.[结论]化浊解毒清幽方加减治疗HPAG疗效满意,值得临床进一步研究和推广.%Objective To observe the effect of Huazhuo Jiedu Qingyou Recipe ( HJQR), which is based on the theory of pathogenesis of turbid toxicity, on the clinical symptoms, gastroscopic features and Helicobacter pylori (HP) infection rate in patients with Helicobacter pylori associated gastritis (HPAG), and to search effective prescription for HPAG. Methods Sixty-four HPAG patients were equally randomized into two groups. The treatment group was treated with oral use of modified HJQR (mainly composed of Herba Taraxaci, Herba Hedyotis Diffusae, Herba Portulacae Grandiflorae, Rhizoma Coptidis, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Radix Paeoniae Alba, Radix Aucklandiae, Rhizoma Corydalis, Radix Notoginseng, and Radix Glycyrrhizae). The control group was given trigeminy regimen which consisted of Rabeprazole capsules, Amoxicillin capsules and Metronidazole tablets. The general state, gastroscopic features and HP eradiation rate were observed before and after treatment. Results The improvement of symptoms and gastroscopic features in the treatment group was superior to that in the control group ( P < 0. 05 ) , but the difference of HP eradiation rate was insignificant (P > 0. 05 ) , which indicated that the effect on HP infection was similar in the two groups. Conclusion Modified HJQR is effective for the treatment of HPAG, and is worth of further research.