子宫动脉栓塞灌注化疗对宫颈癌的局部微淋巴管密度和血管内皮生长因子的影响

摘要

Objective:To investigate the effects of uterine arterial embolization chemotherapy (UACE)on lymphatic microvessel density (LMVD)and vascular endothelial growth factor (VEGF)expression in cervical cancer patients.Methods:112 patients with cervical cancer were randomly divided into an observation group and a control group,with 56 cases in each group.The patients in the observation group received UACE,and those in the control group received intravenous systemic chemotherapy(ISC).The clinical efficacy,the LMVD and positive expression rates of VEGF-A,VEGF-C and VEGF-D were compared.Results:The LMVD and positive expression rates of VEGF-A,VEGF-C and VEGF-D in cervical cancer tissues were significantly higher than those in normal cervical tissues (P＜ 0.05),and were notably lower in the observation group than those in the control group (P＜ 0.05).The response rate in the observation group was significantly higher than that in the control group,whereas the recurrence rate and metastasis rate were significantly lower(P＜0.05).Conclusion:UACE was effective in the treatment of cervical cancer.It could reduce the recurrence and metastasis rates of patients,and the mechanisms might be related to the inhibition of tumor lymphangiogenesis and VEGF expression.%目的:探讨子宫动脉栓塞灌注化疗(UACE)治疗宫颈癌的临床疗效及对局部微淋巴管密度(LMVD)及血管内皮生长因子(VEGF)表达的影响.方法:将宫颈癌患者112例随机分为观察组与对照组,每组56例.观察组实施UACE治疗,对照组实施静脉全身化疗(ISC),比较两组近期疗效及治疗前后宫颈癌组织LMVD、VEGF-A、VEGF-C及VEGF-D表达水平.结果:宫颈癌组织中LMVD和VEGF-A、VEGF-C、VEGF-D表达率显著高于正常宫颈组织(P＜0.05),且观察组治疗后显著低于对照组(P＜0.05);观察组客观有效率显著高于对照组(P＜0.05);观察组复发、转移率分别显著低于对照组(P＜0.05).结论:UACE治疗宫颈癌疗效显著,能够降低复发转移率,其可能机制与抑制肿瘤淋巴管生成和VEGF表达有关.