目的 研究宽叶打碗花全草的脂溶性化学成分.方法 利用硅胶柱色谱、凝胶柱色谱、反相柱色谱和制备液相色谱等方法进行分离纯化,通过理化性质、波谱数据并结合文献鉴定化合物结构.结果 从宽叶打碗花中分离得到了11个化合物,分别鉴定为东莨菪苷(1)、莨菪亭(2)、N-p-香豆酰酪胺(3)、伞形花内酯(4)、邻苯二甲酸二丁酯(5)、邻苯二甲酸二辛酯(6)、大豆脑苷Ⅰ(7)、去氢催吐萝芙木醇(8)、(6R,7aR)-表地芰普内酯(9)、绿原酸甲酯(10)以及β-谷甾醇(11).结论 所有化合物均为首次从该植物中分离得到.%Objective To study the liposoluble chemical constituents from Calystegia sepium (L) RBR. Methods The compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20, ODS column chromatography, preparative HPLC and so on. The structures were identified on the basis of physicochemical properties and the spectroscopic data, as well as literature. Results A total of 11 compounds were separated and identified as scopolin (1), scopoletin (2), N-p-ciscoumaroy-tyramine (3), umbell-iferone (4), dibutyl phthalate (5), dioctyl phthalate (6), soya-cerebroside Ⅰ (7), Dehydrovomifoliol (8), (-) -epiloliolide (9), methyl chlorogenate (10), β-sitosterol (11). Conclusion Compounds 1-11 are isolated from Calystegia sepium for the first time.
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