载药纳米 Fe3O4/羧化壳聚糖磁性液体的制备与表征∗

摘要

采用化学共沉法制备 Fe3 O 4磁性微粒，用水溶性较好的羧化壳聚糖及用于治疗基底细胞瘤、光化性骨化病的氨基酮戊酸对 Fe3 O 4磁性微粒进行两层包覆，最终形成载药 Fe3 O 4/羧化壳聚糖磁性液体。采用 XRD、TEM 和 FT-IR 对载药纳米 Fe3 O 4/羧化壳聚糖磁性液体复合微球的晶型结构、官能团组成及微粒尺寸和形貌等进行了表征。检测结果说明，制备的载药纳米 Fe3 O 4/羧化壳聚糖磁性液体，其核心组份为晶型较好的 Fe3 O 4磁性纳米微粒，磁性微粒的粒径范围为9~11 nm；载药 Fe3 O 4/羧化壳聚糖磁性复合微球成类球状；氨基酮戊酸、羧化壳聚糖和 Fe3 O 4分子间发生了化学键的作用；在外加磁场作用下，观察到载药磁性液体的定向移动，有望实现在肿瘤治疗上的主动靶向给药作用。%Preparation of Fe3 O 4 magnetic particle loading drug by chemical co-precipitation,with carboxylation chitosan and 5-aminolevulinic acid which was mainly used for treatment of basal cell carcinoma and actinic ossifi-cation disease for two layer coated Fe3 O 4 magnetic liquid.The product was by XRD,TEM and FT-IR.Results show that magnetic particles was crystal type of Fe3 O 4 magnetic liquid;Fe3 O 4/carboxyl chitosan composite par-ticle loading 5-aminolevulinic acid was about 1 1 nm in size;the Fe3 O 4/carboxyl chitosan composite particle loading 5-aminolevulinic acid was near-spherical;carboxyl chitosan,5-aminolevulinic acid and Fe3 O 4 molecular presence chemical adsorption;Fe3 O 4/carboxyl chitosan composite particle loading 5-aminolevulinic acid move direction in extra magnetic field,contribute to target administration in cancer therapy.