Objective To investigate the risk factors of type 2 diabetes with depression and its re-lationship with atherosclerosis . Methods The HAMD-17 measuring scale was determined in 184 inpa-tients with type 2 diabetes from Fujian Provincial Hospital . A total of 106 patients with type 2 diabetes with depression were set as the case group (according with the depression of CCMD-3 diagnostic criteria , HAMD-17≥17 points) ,and 78 patients with type 2 diabetes without depression were set as the control group (HAMD-17≤7) . Glycosylated hemoglobin ,lipids ,C-reactive protein (CRP) ,and carotid intima-media thickness (IM T ) were performed in all patients . The risk factors associated with type 2 diabetes with depression ,and its relationship with inflammation and atherosclerosis was analyzed . Results (1) A higher BM I ,abdominal circumference ,incidence of diabetes microvascular complications and more female patients were found in type 2 diabetes with depression group . There are significant differences in treat-ment method between the two groups (P<0 .05) ,but no statistically significant differences in age and du-ration of diabetes between the two (P>0 .05) . (2) The levels of IM T ,CRP ,HbA1c in the case group were significantly higher than those in the control group (P<0 .05) ,while there were no statistically sig-nificant differences in lipids between the two groups (P>0 .05) . (3) In multiple linear regression analy-sis , the HAMD scores were positively correlated with IM T (Standard regression coefficient = 0 .234 , P<0 .05) and also positively correlated with HbA 1c(Standard regression coefficient=0 .348 , P<0 .01) , but no correlation was observed between HAMD scores and CRP (Standard regression coefficient=0 .030 , P>0 .05) . Conclusions Female ,obesity ,poor glycemic control ,microvascular complications and insu-lin therapy might all be the risk factors of type 2 diabetes with depression . Inflammation and atheroscle-rosis are related with the pathogenesis of depression in type 2 diabetes . Type 2 diabetes with depression is associated with both diabetic vascular disease and microvascular disease .%目的探讨2型糖尿病合并抑郁症的相关危险因素及其与动脉硬化关系。方法收集184例2型糖尿病住院患者作为研究对象，入选对象均行HAMD-17量表测评，其中106例2型糖尿病合并抑郁症患者（符合CCMD-3抑郁症诊断标准，HAMD-17≥17分）为病例组，78例2型糖尿病未合并抑郁症患者（HAMD-17≤7分）为对照组；入选对象均行糖化血红蛋白（HbA1c）、血脂、C-反应蛋白（CRP）、颈动脉内膜中层厚度（IMT）等检测。分析2型糖尿病合并抑郁症的相关危险因素，及其与炎症、动脉硬化关系。结果（1）2型糖尿病合并抑郁症组BMI较大、腹围较大、糖尿病微血管并发症发病率较对照组高、女性患者较多，治疗方式存在差异（P＜0．05）；2组年龄、糖尿病病程比较，差别无统计学意义（P＞0．05）；（2）2型糖尿病合并抑郁症组IMT、CRP、HbA1c明显高于对照组，差别具有统计学意义（P＜0．05）；2组血脂比较，差别无统计学意义（P＞0．05）；（3）多元线性回归分析结果显示：HAMD评分与IMT呈正相关，标准回归系数为0．234，P＜0．05，与HbA1c呈正相关，标准回归系数为0．348，P＜0．01，相关性均有统计学意义，HAMD评分与CRP无相关性，标准回归系数为0．030，P＞0．05。结论2型糖尿病患者中女性、肥胖、血糖控制不佳、微血管并发症、使用胰岛素治疗等都是与2型糖尿病合并抑郁症的相关因素；炎症、动脉硬化与抑郁症的发病过程有关，2型糖尿病合并抑郁症与糖尿病大血管病变和微血管病变均有相关。
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