中药保留灌肠及微波治疗在体外受精-胚胎移植中宫腔积液及内膜薄的应用

摘要

Objective To investigate the effect of Chinese medicine retention enema and shortwave therapy on endometrial blood flow changes and clinical pregnancy in infertility patients with uterine cavity effusion and thin endometrium who undergo in vitro fertilization and intracytoplasmic sperm injection. Methods The data of 240 patients with long down-regulation protocol in mid-luteal phase from the Center of Reproduction Maternal And Child Health Care Hospital in Hunan Province,were respectively analyzed. The patients were divided into three groups:Group A -with uterine cavity effusion in treatment (77 cases),Group B-thin endometrium in treatment(43 cases),and Control Group(uterine cavity effu-sion or thin endometrium. We compared between groups,before and after the treatment,and the endom-etrial blood flow and the embryo implantation rates,biochemical,and clinical pregnancy rates. Results The endometrial blood flows of the treatment group(Group-A and Group-B)were significantly improved after the treatment. On the day of implantation the intrauterine membrane blood flow index RI,PI and uterine artery blood flow index RI,PI were significantly reduced than they were on the day of human cho-rionic gonadotropin injection(HCG)(P< 0.05). However between the two treatment groups and the Control Group,there were no significant differences in age,basic FSH,fertilization rate and clinical preg-nancy rate(P>0.05). Conclusion For patients with uterine cavity effusion and thin endometrium un-dergoing IVF-ET,Chinese medicine retention enema and short-wave therapy can effectively improve the endometrial blood flow,improve the embryo implantation rate,and clinical pregnancy rate.%目的 探讨中药保留灌肠及微波治疗对宫腔积液及内膜薄不孕患者在接受体外受精(IVF)和卵泡浆内单精子注射(ICSI)助孕周期中内膜血流改变与临床妊娠的影响. 方法 收集采用黄体中期长方案治疗的患者240例,其中宫腔积液77例,内膜薄43例,余120例未出现宫腔积液或内膜薄(对照组).比较宫腔积液组及内膜薄组在中药保留灌肠及微波治疗前后的内膜血流变化,并比较3组的受精率及临床妊娠率. 结果 宫腔积液组及内膜薄组患者经治疗后血供显著改善,移植日子宫内膜血流阻力指数(RI)及搏动指数(PI)和子宫动脉RI及PI均较扳机日降低(P<0.05);宫腔积液组及内膜薄组的年龄、基础卵泡刺激素(FSH)、受精率和临床妊娠率与对照组比较,差别均无统计学意义(P>0.05). 结论 IVF/ICSI助孕中宫腔积液及内膜薄的患者,经中药保留灌肠及微波治疗后,受精率及临床妊娠率不受影响.