首页>
中文期刊>中国实验血液学杂志
>The expression of human mutant DHFR gene in murine bone marrow and long-term protection of murine hemacytogenesic function from lethal doses of MTX
The expression of human mutant DHFR gene in murine bone marrow and long-term protection of murine hemacytogenesic function from lethal doses of MTX
Chemotherapy is one of the curative treatmentmodality for several types of tumors. However, thedosage of antitumor drugs was limited by cytotoxicityof drugs to normal tissues, especially for bone marrow(myelosuppression). Drug resistantce gene (hMDRI,hDHFR etc.) is expressed in many normal tissues. Itsover-expression in tumor cells give rise to the tumorresistant to many drugs. But, if we transfer the drugresistance gene into the normal hematopoietic stemcell (HSC), the expression of the foreign gene
展开▼