MOLECULAR BIOLOGICAL ASPECTS ON EVOLUTION OF CHRONIC MYELOGENOUS LEUKEMIA TO BLAST CRISIS

摘要

Chronic myelogenous leukemia (CML) isa myeloproliferative disorder that has beenshown to occur at the level of pluripotent stemcells. It is characterized cytogenetically by thepresence of Philadelphia (Ph^1) chromosomewhich originates from the reciprocaltranslocation t(9;22) (q34; q11). This gives riseto the production of an abnormal 8.5kbbcr-abl mRNA and its translation product, a210 kD fusion protein. At present, it isknown that the chimeric bcr-abl hybrid