人CD4+FOXP3+T细胞的异质性研究进展

摘要

It is now established that CD4 + CD25 + regulatory T (Treg) cells expressing transcription factor FOXP3 ,a regulatory subpopulation of T cells, is indispensable for the maintenance of immunological self-tolerance and immune homeostasis. FOXP3 expression in Treg cells is specific and it is the key control factor for the development, activation and function of Treg cells. At present, CD4+ FOXP3 + T lymphocytes are often used to define Treg cells for scientific research. But recent studies show that human CD4 + FOXP3 + T cells are phenotypically and functionally heterogeneous, including suppressive and nonsuppressive T cells. The different functions of these cell subsets can be distinguished by phenotypic differences. This review discusses the recent research progress about phenotypic characteristics and functional heterogeneity of CD4 + FOXP3 + T cell subsets.%CD4+ CD25+调节性T细胞(Treg)是一群具有免疫调节功能的细胞,对维持自身免疫耐受和免疫自稳必不可少,FOXP3特异性表达于Treg细胞,是Treg细胞发育、活化、发挥功能的关键.目前,CD4+ FOXP3+T淋巴细胞常被用来定义Treg细胞进行科学研究,而最近研究表明,人CD4+ FOXP3+T淋巴细胞存在表型和功能上的异质性,这其中包括具有免疫抑制功能的CD4+ FOXP3+ Treg,还包含没有抑制功能的其它类型T细胞,而这些不同功能的细胞亚群可以通过表型的差异加以区分.本文就近年来关于CD4+ FOXP3 +T细胞亚群表型特征和功能的异质性研究作一综述.