吉兰-巴雷综合征早期电生理变化特点分析

摘要

To analyze the; early electro physiological characteristic of Guillain-Barre syndrome; (GBS) and to discuss its value; of the; diagnosis in the; early stage; of GBS . Methods Retrospective analysis method was used to assess the electro physio logical examination and clinical characteristis in 69 patients ,with GBS .The electrophysiological characteristic within 7 days after the onset of symptom and that of more; than 7 days after the; onset of symptom were analyzed respectively . Results :The motor NCV was abnormal in 55% of the; patients ,within 7 days after symptom in 45% and in 7 days and after more; than 7 days in 50% .The; F waves were abnormal in 77% ,in 52% and after more; than 7 days in 48% .The; se;nsory NCV was abnormal in 52% of the; patie;nts ,within 7elays and afte;r more; than 7 days in 50% .The; (compound muscle; ae-tion potential (CM AP) amplituded ele;e-re;ase;D in 64% of the; patie;nts ,within 7elays in 52% afte;r the; onse;t of symptom and after more; than 7 days in 48% .Abnormal nppe;r e;xtre;mity SNAP ae-e-ompany a normal snral SNAP ae-count for 39% ,within 7elays afte;r the; onse;t of symptom in 44% anel after more; than 7 elays in 56% .Conclusion :NCV ,F waves , abnormal upper extremity SNAP/ normal snral SNAP are; effective; anel important auxiliary examination for diagnosis in the; e;arly stage; of GBS . They can improve; the; diagnosis le;vel .%目的:分析吉兰-巴雷综合征(GBS)早期(1～7 d)的电生理改变特点,探讨其对GBS的早期诊断价值.方法:采用回顾性分析方法对69例GBS患者的电生理检测结果与临床特点进行分析,比较发病7 d之内和大于7 d的神经电生理变化特点.结果:运动神经传导速度(MCV)的异常率为55%,发病7 d内为45%,发病7 d后为55%;F波异常率为77%,发病7 d内为52%,发病7 d后为48%,感觉神经传导速度(SCV)异常率为52%,发病7 d内及7 d后均为50%;运动神经复合肌肉动作电位(CMAP)波幅降低异常率为64%,发病7 d内为52%,发病7 d后为48%;上肢感觉神经动作电位(SNAP)异常同时伴有腓肠神经SNAP正常者占39%,发病7 d内占44%,发病7 d后为56%.结论:GBS患者早期(7 d之内)即可出现神经传导速度、F波、运动及感觉神经传导的改变,以F波更为明显,因此神经电生理检查在GBS中的早期诊断具有重要的作用.