电针呼循穴区对心律失常模型大鼠的影响

摘要

Objective: To observe the effects of electro-acupuncture (EA) in arrhythmia rats via ECG,plasma cAMP and cGMP levels. Methods: Experimental arrhythmia model was induced by BaCl2 in rats with EA on Huxun point area or lateral line 1 of fore-head or intravenous inject lidocaine. Some indices were observed such as the ECG,the cAMP and the cGMP. Results: After the EA on Huxun point area,the heart rate and the car-dioversion time were decreased. Levels including cAMP and cAMP / cGMP were reduced. The effect of EA on Huxun point area was similar to EA on lateral line 1 offore-head. Moreover,the intravenous inject lidocaine had the strongest effect. Conclusion: EA on Huxun point area has an obvious curative effect in arrhythmia rats. Its mechanism maybe related to the meridians,the autonomic nervous system,the cAMP and the cGMP.%目的 观察电针“呼循穴区”对心律失常大鼠的心电图及血浆环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)水平的影响.方法 采用BaCl2诱发大鼠心律失常模型,电针大鼠呼循穴区,观察实验前后各时刻大鼠心电图变化,检测干预后大鼠血浆cAMP、cGMP含量,并与电针额旁1线,舌下静脉注射0.5％利多卡因进行对比.结果 电针呼循穴区能减慢心律失常大鼠心率、缩短复律时间,降低血浆cAMP、cAMP/cGMP水平,电针呼循穴区与额旁1线效果相当,0.5％利多卡因效果最强.结论 电针呼循穴区对心律失常大鼠有明显的改善作用,其作用机制可能与经络、自主神经系统,血浆cAMP、cGMP水平有关.