伏风理论对慢性阻塞性肺疾病急性期抗炎效果的临床研究∗

摘要

目的：观察运用伏风理论治疗慢性阻塞性肺疾病急性期（AECOPD）的疗效及分析其抗炎机制。方法选择80例AECOPD患者随机分为对照组（西医常规治疗）和治疗组（西医常规治疗加伏风协定方）各40例，观察两组治疗前后主要症状体征的积分及肺功能变化评价疗效。观察两组治疗前后血清白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）和C反应蛋白（CRP）水平及诱导痰液炎症细胞水平，分析其抗炎作用机制。结果治疗组临床症状总有效率优于对照组；治疗组炎症细胞和中性粒细胞分类均较对照组有显著性差异；血清IL-6、IL-8、TNF-α、CRP水平及肺功能（FEV1、FEV1%、FEV1/FVC）均优于对照组（均P<0.05或P<0.01）。结论运用伏风理论指导治疗AECOPD的抗炎效果显著。%Objective:To observe the therapeutic effect for AECOPD directed by the theory of“latent wind”and to analyse its anti-inflammatory effect. Methods:80 AECOPD patients were randomly divided into control group(given routine medical treatment)and treatment group(given routine medical treatment plus the agreed la⁃tent-wind formula),each contains 40 cases. Points of main symptoms and signs of two groups before and after treatment were analysed,and changes of pulmonary function of two groups before and after treatment were ob⁃served to evaluate therapeutic effect. Levels of serum IL-6,IL-8,TNF-α and CRP and inflammatory cells in in⁃duced sputum in two groups before and after treatment were recorded to analyse their anti-inflammatory effect. Results:Total effective rate of the treatment group was superior to that of the control group;There was signifi⁃cant difference in the inflammatory cell classifications and neutrophil percentages between the treatment group and the control group;Serum IL-6,IL-8,TNF-α,CRP level and pulmonary function(FEV1、FEV1%、FEV1/FVC) in the treatment group are all better than that in the control group. Conclusion:The anti-inflammatory effect of the treatment directed by the"Latent Wind"theory is evident.