催乳素在绵羊季节性发情中的调控作用

摘要

催乳素(prolactin,PRL)是一种蛋白激素,由垂体前叶嗜酸细胞、妊娠子宫蜕膜和免疫细胞等分泌,在哺乳动物和禽类繁殖中发挥着重要作用.小鼠与禽类中PRL可调控繁殖性状,影响垂体中促性腺激素的分泌及卵巢中卵泡的生长.绵羊休情季节可维持高浓度PRL,发情季节PRL浓度降低.论文主要对PRL所涉及的调控网络及PRL对下丘脑-垂体-性腺轴的调控作用进行综述,分析PRL在绵羊季节性发情中可能的调控作用,为深入探索动物季节性发情调控机制提供参考.%Prolactin (PRL), a protein hormone which is secreted by anterior pituitary acidophil, the deciduas of pregnant uterine and immune cells, plays an important role in reproduction of mammals and birds.PRL can regulate reproductive traits in mice and poultry, affecting pituitary gonadotropin secretion and the growth of follicle in ovary.The concentration of ovine PRL is high in anestrus, while it is low in breeding season.Then, how does PRL regulate ovine seasonal estrus? In order to answer it, the regulatory network of PRL secretion and the regulatory roles of PRL on hypothalamus-pituitary-gonadal axis were reviewed, and on this basis, the probable regulatory modes of PRL in ovine seasonal estrus were analyzed.The results will provide information for further exploration in the regulation mechanism of animal seasonal reproduction.