云南紫皮玛咖醇提取物对高脂血症降脂作用的初步研究

摘要

Objective:Through establishing models of hyperlipidemia in rats,to carry out a preliminary research on lipid-lowering effects of maca.Methods:Fifty male Wistar rats of 5 weeks old were randomly divided into 2 groups,10 in the control group and 40 in the model group.Successfully modeled rats were randomly divided into 4 groups according to body weight,with 10 rats in each group.The high-dose group was given by gavage with 0.68 g/kg of ethanol extract of maca daily; the low-dose group was given by gavage with 0.34 g/kg of ethanol extract of maca daily; the positive control group was given by gavage with 20 mg/kg of simvastatin daily.After 15-week gavage,the levels of TG,TC,HDL and LDL in rats'serum were detected.Results:The levels of TG,TC,HDL and LDL in the blank group were lower than those in the negative group; the levels of TC and LDL in the positive group were lower than those in the negative group; the levels of TC and LDL in the high-dose group were lower than those in the negative group; the level of TC in the low-dose group is lower than that in the negative group.The above results were significantly different(P ＜0.01).Conclusion:Ethanol extract of maca has had lipid-lowering effects on hyperlipidemia Wistar rats.Low doses of ethanol extract can reduce the level of TC,while high doses of ethanol extract can reduce both levels of TC and LDL.%目的:通过建立大鼠的高脂血症模型,对玛咖的降血脂作用进行基础性的研究.方法:5周龄的雄性Wistar大鼠50只,随机分为2组,10只作为对照组,40只作为建模组.将已建模成功的大鼠,依据体重随机分成4组,每组10只.高剂量组以玛咖醇提取物0.68 g/kg每日灌胃;低剂量组以玛咖醇提取物0.34 g/kg每日灌胃;阳性对照组以辛伐他汀20 mg/kg每日灌胃.灌胃15周检测大鼠血清中TG、TC、HDL、LDL水平.结果:空白组TG、TC、HDL、LDL比阴性组低;阳性组TC、LDL比阴性组低;高剂量组TC、LDL比阴性组低;低剂量组TC比阴性组低.以上结果差异均有统计学意义(P＜0.01).结论:玛咖醇提取物对高脂血症Wi?star大鼠有降血脂作用,低剂量玛咖醇提取物可降低TC水平,高剂量玛咖醇提取物可降低TC、LDL水平.