血清IL-15、IL-18与急性胰腺炎预后的相关性研究

摘要

目的 探讨血清IL-15、IL-18水平与急性胰腺炎预后的相关性.方法 采用ELISA法分别测定正常对照组、轻型急性胰腺炎(mild acute pancreatitis,MAP)组及重症急性胰腺炎(severe acute pancreatitis,SAP)组第1、7、14天的IL-15、IL-18水平.结果 MAP组的血清IL-15、IL-18水平明显高于正常对照组(P＜0.05),而SAP组的血清IL-15、IL-18水平较正常对照组升高更为明显(P＜0.01);SAP组的血清IL-15、IL-18水平亦明显高于MAP组(P＜0.05).结论 IL-15、IL-18与急性胰腺炎严重程度密切相关,其血清水平可作为判断急性胰腺炎严重程度的指标之一.%Objective To explore the relationship between serum levels of interleukin (IL)-15,IL-18 and the prognosis of patients with acute pancreatitis. Methods Serum levels of IL-15.IL-18 were measured by ELISA assay in all patients with mild acute pancreatitis (MAP) or severe acute pancreatitis (SAP) on the lth,7th,and 14th days compared with those from 30 healthy volunteers who acted as control. Results The serum levels of IL-15,IL-18 in MAP as well as in SAP patients were higher than those of healthy subjects. Furthermore,the serum levels of IL-15.IL-18 in patients with SAP were significantly higher than those of patients with MAP. Conclusion IL-15.IL-18 were all positively correlated with the severity of acute pancreatitis,those serum levels maybe acted as the markers to the severity of acute pancreatitis,