Objective investigate the distribution characteristics and pattern of DR-TB in ditterent types of suspected pulmonary MDR-TB patients and provide scientific evidence for MDR-TB control in DongYing. Methods All suspected MDR-TB found during October 2007 to April 2010 were investigated. Sputum smear, culture, bacterial identification and drug susceptibility test were performed for diagnosis of MDR-TB. Statistical analysis was made for the incidence rate of DR-TB and MDR-TB in different types of pulmonary MDR-TB patients. Results 424isolated strains ofMycobacterium tuberculosiswere tested for drug susceptibility, 36. 2％ of them were diag-nosed as MDR-TB; Among 147 cases of MDR-TB, initial treatment, re-treatment and new patients accounted for 28.6％, 70. 1％ and 1.3％ respectively. constituted the highest portion in retreatment failure category under retreatment group. In MDR-TB cases, the highest frequency is resistance to HRS and HRES in initial treatment group and HR and HRES in retreatment group. For other DR-TB patients, the majority is single drug resistance with highest frequency in H and R resistance. Conclusions Retreatment group was the major category for MDR-TB occurrence, however, there are also high MDR-TB incidence in those with smear positive results after 3 months treatment and those with initial treatment failure( in fact, these are already retreatment eases). Drug resistance is serious in both new and retreatment group. And other DR-TB is high risk population for MDR-TB.%目的 研究耐药结核病(DR-TB)在不同类型可疑耐多药结核病人(MDR-TB)中的分布特点及其耐药谱分布情况.方法 2007年10月～2010年04月胜利油田发现的可疑耐多药结核病人为研究对象,通过痰涂片、培养、菌种鉴定和药物敏感试验诊断MDR-TB,按照可疑MDR-TB患者不同肺结核类型发生耐药和耐多药结核病情况进行统计分析.结果 406例临床分离菌株药物敏感试验,其中36.2%为MDR-TB,18.9%为其他DR-TB;147例MDR-TB病例中,初治占28.6%,复治70.1%,新患者1.3%.复治组中复治失败病例的MDR-TB发生率最高.结论 复治组是MDR-TB发生的主要类别,但3个月末涂阳和初治失败患者也存在较高的MDR-TB发生率.
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