杏根青龙汤对慢性阻塞性肺疾病患者气道炎症及气道重塑的影响

摘要

Objective To study the effects of Xinggenqinglongtang decoction on the cell counts and the levels of IL-8 and MMP-9 in induced sputum in patients with chronic obstructive pulmonary disease(COPD). Methods A total of 80 patients with stable COPD were enrolled and randomly divided into 2 groups:test group and COPD control group. 40 nonsmoke healthy individuals were enrolled in control group. All patients with COPD were treated with salmeterol/fluticasone (50ug/lOOug). The test group was treated with Xinggenqiongtang Decoction. The cell counts and the levels of IL-8 and MMP-9 were measured in all cases. Results The total cell counts and the percentage of neutrophils cell counts and sputum supernatant concentration of MMP-9 of COPD were decline in test group and COPD control group. The total cell counts and the percentage of neutrophils cell counts and sputum supernatant concentration of MMP-9 of COPD were lower in test group than that of the COPD control group after treatment. The sputum supematant concentration of IL-8 of COPD was decline slightly in all groups. Conclusions Administration of Xinggenqiongtang Decoction decreased the total cell counts and the percentage of neutrophils cell counts and the increased expression of MMP-9.%目的 检测杏根青龙汤对慢性阻塞性肺疾病患者诱导痰细胞、IL-8和MMP-9的影响,以探讨杏根青龙汤对COPD患者气道炎症及气道重塑的影响.方法 将80例稳定期COPD患者随机分为治疗组和COPD对照组.另有40例非吸烟健康志愿者作为健康对照组.所有COPD患者均接受沙美特罗替卡松粉(50 μg/100 μg)吸入.治疗组另给予杏根青龙汤口服.治疗前后分别检测诱导痰细胞、白细胞介素8(IL-8)和基质金属蛋白酶9(MMP-9)水平.结果 治疗后,治疗组和COPD对照组诱导痰细胞总数、中性粒细胞比例和MMP-9水平均有所下降.治疗组下降的程度优于COPD对照组.治疗前后诱导痰IL-8水平无统计学差异.结论 杏根青龙汤可以有效降低诱导痰细胞总数、中性粒细胞比例和MMP-9水平.