AECOPD氧化应激与肺功能、最大呼吸肌力动态变化相关性研究

摘要

Objective To study the correlative relationship among oxidative stress and lung function, maximal respiratory muscle strength in patients with COPD in acute exacerbation period. Methods Serum concentrations of malondialdehyde (MDA), glutathione ( GSH), glutathione disulfide (GSSG), superoxide dismutase (SOD) were detected in 47 patients with COPD in acute exacerbation period through ELISA, which were correlatively analyzed to yearly-decreased value of forced expiratory volume in one second ( △FEV1) , forced vital capacity ( △FVC), and maximal inspiratory pressure ( △MIP). Results There were a positive correlative relationship between MDA and △FEV1, a negatively correlated relationship between GSH,GSH/GSSG and △FEV1 respectively, a negatively correlated relationship between GSH and A MIP. There was no other significant relationships reported. Conclusion Oxidants/antioxidants imbalance deteriorates lung function and maximal respiratory muscle strength in patients with COPD in acute exacerbation period.%目的 研究AECOPD患者氧化应激与肺功能、最大呼吸肌力动态变化的相关性.方法ELISA检测47例COPD急性加重期患者血清丙二醛(MDA)、谷胱甘肽(GSH)、氧化型谷胱甘肽(GSSG)、超氧化物歧化酶(SOD)浓度,与其第一秒钟用力呼气容积( FEV1)、用力肺活量(FVC)、最大吸气压(MIP)年下降值进行相关性分析.结果 MDA与FEV1年下降值呈正相关,GSH、GSH/GSSG与FEV1年下降值呈负相关,GSH与MIP年下降值呈负相关.结论 COPD急性加重期氧化/抗氧化失衡加速COPD的肺功能下降和呼吸肌力的减弱.