AECOPD伴重度Ⅱ型呼吸衰竭患者IPPV临床疗效及预后危险因素分析

摘要

目的 分析AECOPD伴重度Ⅱ型呼吸衰竭患者IPPV临床疗效及预后危险因素.方法 总结近5年我科收治的64例患者的临床资料,按其临床预后分组,并比较各组的一般资料、治疗前后动脉血气及各种生化指标的变化.结果 1.动脉血气指标(PH、PaCO2、PaO2、SaO2)均得到显著改善 (P＜0.05).2.入院时血红蛋白含量、治疗后中性粒细胞百分比、白蛋白含量、及通气天数是的预后不良的独立危险因素.结论 IPPV是抢救、治疗AECOPD伴重度Ⅱ型呼吸衰竭的有效且可靠的手段,积极处理可干预的危险因素是提高临床疗效的关键.%Objective To analyze the curative effect and prognostic risk factors of invasive positive pressure ventilation ( IPPV ) in the treatment oi AECOPD patients complicated with severe Ⅱ type, respiratory failure so as to improve therapeutic efficiency. Methods The clinical data oi 64 patients with AECOPD complicated with severe Ⅱ type respiratory failure were analyzed. The changes oi arterial blood gas and other biochemical indexes before and after mechanical ventilation were observed and compared. Results 1. The indicators oi arterial blood gas analysis ( PH, PaCO2 , PaO2 , SaO2 ) were all improved significantly after the treatment oi IPPV ( P < 0. 05 or P < 0. 01 ). 2. The independent risk factors oi poor prognosis were the content oi hemoglobin before the treatment, the content oi neutrophil percentage, albumin content and ventilation days. Conclusion 1. IPPV is an effective and reliable method to rescue and treat AECOPD patients complicated with severe Ⅱ type respiratory failure. 2. Pertinent intervention on these prognostic risk factors is the key to improve the clinical curative effect.