早期应用复合乳酸菌预防呼吸机相关肺炎的临床疗效及对炎症因子的影响研究

摘要

Objective To evaluate the influence of compound lactobacillus on the level of inflammatory fac-tors and the prevention of ventilator associated pneumonia. Methods 300 patients under mechanical ventilation were enrolled in this study and were randomly and equally divided into two groups, the study group and the control group. The clinical index of VAP incidence, mortality, therapeutic effect and hospital stay were compared between the two groups. The levels of TNF-α, PCT and HSCRP were also detected. Results The incidence of VAP was lower in the study group (26% ) than in the control group (48% ), the occurrence time of VAP was later in the study group than in the control group, and the duration of hospital stay was shorter in the study group than in the control group (P <0. 05). The levels of inflammatory factors were lower in the study group than in the control group 4 days after the treatment (P < 0. 05). Conclusion The early administration of compound lactobacillus in patients under mechanical ventilation can effectively prevent the VAP development.%目的：探讨早期应用复合乳酸菌预防呼吸机相关肺炎的临床疗效及对炎症因子的影响。方法连续性纳入2014年1月至12月 ICU 住院治疗的300例重症患者，随机平均分为益生菌组和对照组。比较两组患者 VAP 发生率、病死率、临床治疗效果以及 ICU 住院时间等临床指标。同时分析比较降钙素原以及超敏 C 反应蛋白和肿瘤坏死因子α水平改变。结果益生菌组患者 VAP 发生率明显低于对照组(26% vs 48%)(P <0．05)，并且益生菌组患者出现 VAP 的时间明显晚于对照组(P <0．05)，平均 ICU 住院时间方面，益生菌组也明显优于对照组(P <0．05)。在治疗早期(治疗后第4天)益生菌组炎症因子水平均明显低于对照组(P <0．05)。结论机械通气患者早期使用复合乳酸杆菌制剂可以有效预防 VAP 的发生。