目的：本研究旨在探讨 GPRC5A、SOCS3、STAT3在非小细胞肺癌(non-small cell lung cancer, NSCLC)中的表达与 NSCLC 临床特征的关系及三者之间的相关性。方法运用免疫组织化学 Elivision 法检测 GPRC5A、SOCS3、STAT3在 92例 NSCLC 中的表达情况,随机抽取40例的癌旁正常组织作为对照,并对三者进行相关性分析。结果在 NSCLC 中 GPRC5A、SOCS3、STAT3的阳性表达率分别为43．4%(40/92)、44．6%(41/92)、76．0%(70/92),而在癌旁组织中三者的阳性率分别是77．5%(31/40)、100%(40/40)、32．5%(13/40),三者与 NSCLC 的分化、分期、淋巴结转移密切相关(P <0．05),GPRC5A 与 SOCS3在 NSCLC中呈正相关( r =0．537, P <0．05)、SOCS3与 STAT3呈负相关( r =-0．369,P <0．05)。结论 GPRC5A、SOCS3、STAT3在 NSCLC 的发生和发展中起重要作用,且三者之间存在显著相关性,为深入研究其调控路径提供了依据,为肺癌的靶向治疗提供了新的思路。%Objective To investigate the expression of GPRC5A, SOCS3 and STAT3 in non-small cell lung cancer (NSCLC), in order to analyze their relationship with the clinical pathologic features. Methods The immu-nohistochemical staining method was used to detect the expression of GPRC5A,SOCS3 and STAT3 in 92 NSCLC pa-tients and 40 normal pericarcinous tissues. The correlation between the expression of these proteins was analyzed. Results The positive rate of GPRC5A, SOCS3 and STAT3 expression were 43. 4% (40 / 92), 44. 6% (41 / 92) and 76. 0% (70 / 92) respectively in NSCLC tissues, and 77. 5% (31 / 40), 100% (40 / 40) and 32. 5% (13 / 40) in normal pericarcinous tissues. The expression level of GPRC5A, SOCS3 and STAT3 was closely related with cell dif-ferentiation, clinical stages and lymph node involvement (P < 0. 05). GPRC5A protein expression was positively cor-related with the expression of SOCS3 protein (r = 0. 537, P < 0. 05). SOCS3 protein expression was negatively corre-lated with the expression of STAT3 protein (r = - 0. 369, P < 0. 05). Conclusion The expression of GPRC5A, SOCS3 and STAT3 plays an important role in the occurrence and development of NSCLC, and there is a significant correlation among the three indexes. , which provides new ideas for the targeted therapy of lung cancer.
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