慢性阻塞性肺疾病合并抑郁症患者心肺运动试验研究

摘要

Objective To observe the changes of related indexes in COPD patients complicated with depres-sion by cardiopulmonary exercise test (CPET) to study the effect of depression on COPD patients. Methods 85 pa-tients with stable COPD were divided into the depression group and the non-depression group according to Zung self-rating depression scale (SDS), and all of them were given CPET. Results (1) A total of 26 patients were compli-cated with depression, accounting for 30. 6% . (2) Compared with the non-depression group, the depression group had a higher level of shortness of breath (P < 0. 05), despite of similar respiratory functional impairment. (3) 4 ca-ses quitted. The value of peak oxygen consumption and anaerobic threshold percentage of predicted peak oxygen up-take (AT% pred) was lower in the depression group than in the non-depression group, and the slope of ventilatory e-quivalent for carbon dioxide output was higher in the depression group than in the non-depression group (P < 0. 05). Conclusion Depression occurs in more than 30% of stable COPD patients and has a negative impact on ventilatory function and exercise capacity.%目的：观察稳定期慢性阻塞性肺疾病(简称慢阻肺)合并抑郁症患者心肺运动试验(CPET)各参数变化，研究抑郁症对慢性阻塞性肺疾病的影响。方法入选了稳定期慢阻肺患者85例，根据 Zung 抑郁自评量表(SDS)分成抑郁组和对照组，并分别进行 CPET。结果(1)合并抑郁症患者共26例，占慢阻肺总人数30.6%。(2)与非抑郁组相比，抑郁组具有相似水平的肺功能损害，但表现出更加明显的呼吸困难(P <0．05)。(3)共4例患者未能完成试验，完成试验的患者结果显示抑郁组在峰值摄氧量(VO2peak )、无氧阈占预估峰值摄氧量百分比(AT% pred)低于非抑郁组、而二氧化碳通气当量斜率(VE/ VCO2 slope )高于非抑郁组，差异有统计学意义(P <0．05)。结论超过30%的稳定期慢阻肺患者合并存在抑郁症，且其对患者通气功能和运动能力产生负面影响。