葡萄糖转运蛋白1在恶性胸腔积液的表达及意义

摘要

目的：评价葡萄糖转运蛋白l(GLUT-1)在恶性胸腔积液中的诊断价值。方法采用免疫细胞化学SP法检测肿瘤性和非肿瘤性胸腔积液中脱落细胞GLUT-1的表达以及ELISA法测定胸水中GLUT-1的水平。结果两组胸液脱落细胞GLUT-1的表达率恶性组为89．33%,良性组为3．17%,两组间具有统计学差异(P<0．01)；两组胸液上清中GLUT-1的表达水平恶性组为(1．18±0．35)pg/ml,良性组为(0．85±0．24) pg/ml,两组间具有统计学差异(P<0．05)。结论 GLUT-1对恶性胸腔积液的诊断具有较高的敏感度,可以作为鉴别恶性胸腔积液的可靠标记之一。%Objective To investigate the diagnostic value of glucose transporter-1 ( GLUT-1 ) in malignant pleural effusion. Methods The levels of GLUT-1 in neoplastic pleural effusion and non-neoplastic pleural effusion exfoliated cells were determined by immunohistochemistry SP method, and the levels of GLUT-1 in pleural effusion serum were detected by enzyme-linked immunosorbent assay. Results The expression of GLUT-1 of pleural effusion exfoliated cells in the malignant group was 89. 33% and 3. 17% in the benign group (P <0. 01). the levels of GLUT-1 of pleural effusion serum t were (1. 18 ± 0. 35) pg/ml in the malignant group and (0. 85 ± 0. 24) pg/ml in the benign group (P<0. 05). Conclusion GLUT-1 has a higher sensitivity in diagnosis of malignant pleural effu-sions, which can be used as a reliable marker in identification of malignant pleural.