IL-5、IL-10及 FENO 三种炎性标记物诊断成人支气管哮喘的临床价值

摘要

Objective To discuss the role and value of IL-5,IL-10 and FENO in the diagnosis of adult with bronchial asthma,in order to provide reference and guidance for the development of clinical work. Methods 106 a-dult patients with bronchial asthma from October 2014 to December 2015 in our hospital were selected as the case group,at the same time,106 cases of healthy people were selected as the control group. Their serum IL-5 and IL-10 concentrations were measured by enzyme-linked immunosorbent assay(ELISA),the exhaled FENO concentration was measured by FENO test instrument. FENO concentration measurement in the diagnosis value of bronchial asthma was evaluated by ROC curve. The levels of IL-5,IL-10 and FENO between the bronchial asthma group and the normal control group were compared,and the value of IL-5,IL-10 and FENO in the diagnosis of adults with bronchial asthma was defined. Results IL-5,IL-10 and FENO levels were different between the case group and the control group,the serum concentrations of IL-5 in the two groups were respectively(23. 65 ± 13. 86)pg/ mL and(11. 65 ± 2. 79) pg/ mL. The concentration of IL-10 in the two groups were(19. 78 ± 14. 25)pg/ mL and(39. 21 ± 12. 18)pg/mL. The level of FENO of the two groups were respectively(63. 18 ± 31. 62)ug/ L and(26. 74 + 18. 51)ug/ L, and the difference between the two groups was statistically significant(P < 0. 05). Conclusion IL-5,IL-10 and FENO levels are important reference indicators in the diagnosis of adult patients with bronchial asthma,and its exami-nation is beneficial to the early diagnosis. The combined detection of bronchial asthma in adults is conducive to the early diagnosis and prevention and individualized treatment of development.%目的：探讨 IL-5、IL-10及 FENO 三种炎性标记物在诊断成人支气管哮喘中的作用及价值，为临床工作提供参考及指导。方法选取2014年10月-2015年12月期间经我院收治的106例成人支气管哮喘患者作为病例组，同时选取同期来我院进行体检的106例健康人群作为对照组，应用酶联免疫吸附法（ELISA）对所有研究对象的血清 IL-5、IL-10浓度进行测定，应用 FENO 测试仪测定其呼出气 FENO 浓度，比较支气管哮喘组及正常对照组之间的 IL-5、IL-10及 FENO 水平，明确 IL-5、IL-10及 FENO 三种炎性标记物在成人支气管哮喘诊断中的价值。结果病例组及对照组间的 IL-5、IL-10及 FENO 水平存在差异，两组的血清IL-5浓度分别为（23.65±13.86）pg/ mL 和（11.65±2.79）pg/ mL；两组的 IL-10浓度分别为（19.78±14.25）pg/ mL 和（39.21±12.18）pg/ mL；两组的 FENO 水平分别为（63.18±31.62）ug/ L 和（26.74±18.51）ug/ L，两组间差异具有统计学意义（P <0.05）。结论 IL-5、IL-10及 FENO 水平是成人支气管哮喘患者诊断过程中的重要参考指标，对其进行联合检测有利于成人支气管哮喘的早期诊断、预防及个体化治疗的开展。