509株金黄色葡萄球菌感染的临床分布和耐药性分析

摘要

Objective To investigate the clinical distribution and drug resistance of staphylococcus aureus in Beijing Anzhen Hospital from 2011 to 2014.Methods The bacteria were identified by vitek-Compact system and Phoenix 100 system,and the drug resistance test was performed by MIC method.Results 509 strains of staphylo-coccus aureus (SAU)were isolated from clinical specimens,including 286 strains (56.2%)of methicillin -resist-ant Staphylococcus aureus (MRSA).The source of specimens were mostly from respiratory tract (52.1%),followed by blood (13.6%)and wound exudates (11.8%).The distribution of department followed by ICU (31.9%),car-diac surgery ward (11.6%)and respiratory medical ward (9.0%).In 16 types of the antibiotics,the top 3 of the drug resistant rate were:penicillin 97.4%,erythromycin 74.1% and clindamycin 69.9%.The drug resistant rate to vancomycin,linezolid,tygaci and Quinupristin -Dalfoprisdn were 100%.Conclusion Due to the high drug resist-ant rates of S.aureus,drugs should be chosen according to the results of drug susceptibility test.%目的：了解北京安贞医院金黄色葡萄球菌（SAU）在2011～2014年中的临床分布和耐药情况，为临床合理用药提供指导。方法回顾性分析2011年1月至2014年12月临床标本分离的509株 SAU 的分布及耐药性。采用 vitek-Compact 系统和 Phoenix 100系统进行细菌鉴定，MIC 法进行体外抗菌药物敏感试验。结果临床分离金黄色葡萄球菌（SAU）509株。SAU 中有耐甲氧西林金黄色葡萄球菌（MRSA）286株，占56.2％。标本来源依次为呼吸道（52.1％）、血液（13.6％）和伤口分泌物（11.8％）。科室依次是重症监护室（31.9％）、心脏外科病房（11.6％）和呼吸内科病房（9.0％）。SAU 对16种抗菌药物耐药率排在前3位的是青霉素占97.4％、红霉素占74.1％及克林霉素占69.9％；对利奈唑胺、万古霉素、替加环素和奎奴普丁－达福普丁的敏感率约为100％。结论我院分离的 SAU 耐药严重，尤其是 MRSA 多药耐药严重，在治疗金黄色葡萄球菌感染时应根据实验室结果合理选用敏感的抗菌药物。