初治肺结核患者维生素D与其受体基因多态性位点FokI的相关性分析

摘要

Objective To analyze the correlation between vitamin D (VD) and vitamin D receptor (VDR) genetic polymorphism site FokI in newly diagnosed pulmonary tuberculosis patients.Methods 180 newly diagnosed pulmonary tuberculosis patients (PTB) and 100 healthy control were randomly selected.Their serum VD levels and VDR genetic polymorphism site FokI were detected and compared.Results Serum VD level was significantly lower in the PTB group than in the control group (P<0.0001).The deficiency of VD was significantly higher in the PTB group (70.5%) than in the control group (47.0%).The difference of the three genotypes (homozygous FF, homozygous ff and heterozygous Ff) of VDR polymorphism site FokI in the two groups was statistically significant (P=0.033).The rate of homozygous ff and allele f in the PTB group was significantly higher than that in the control group (P<0.05).The level of VD in the ff group was significantly lower than in the FF group and the Ff group in PTB (P<0.05).Conclusion The level of serum VD decreases significantly in newly diagnosed PTB.VDR genetic polymorphism site FokI genotype ff is the susceptibility gene of PTB.%目的 分析初治肺结核患者血清维生素D(VD)与维生素D受体(VDR)基因多态性位点FokI的相关性.方法 对我院随机选取的180位初治肺结核患者和100位正常对照的血清VD水平,VDR基因多态性位点FokI基因型进行检测,比较和分析2组血清VD水平与VDR基因FokI多态性差异以及相关性.结果 初治肺结核患者血清VD水平明显低于正常对照组(P<0.0001);初治肺结核组VD营养缺乏率(70.5%)明显高于正常对照组(47.0%),VDR基因多态性位点FokI的三种基因型(纯合子FF,纯合子ff和杂合子Ff)在两组内的分布差异具有统计学意义(P=0.033),初治肺结核组纯合子ff及等位基因f比率明显高于正常对照组(P<0.05);初治肺结核患者基因型ff组VD水平明显低于基因型FF组和基因型Ff组(P<0.05).结论 初治肺结核患者血清VD水平明显下降,VDR 基因多态性位点FokI基因型ff为肺结核易感基因.