目的 探讨慢阻肺患者FeNO值的临床意义.方法 分别测定健康对照组,稳定期慢阻肺组,AECOPD组各50人的FeNO值,比较各组差异,评估慢阻肺组的FeNO值与肺功能,吸烟等的关系.结果 正常对照组的FeNO值、稳定期慢阻肺组的FeNO值和AECOPD组的FeNO值逐步升高,有显著性差异(P<0.05).稳定期慢阻肺组与AECOPD组无显著性差异(P>0.05).吸烟组FeNO值低于不吸烟者组,有显著性差异(P<0.05).在AECOPD组中不同GOLD分级的组间,随着肺功能的下降,FeNO值随之下降,有显著性差异(P<0.05).结论 FeNO值可用于检测慢阻肺患者中的气道炎症.在急性加重期可评估病情严重程度.吸烟导致FeNO值降低.%Objective To investigate the clinical significance of FeNO value in COPD patients.Methods The study selected 50 healthy people as the control group, 50 stable COPD patients as the group A and 50 AECOPD patients as the group B.Their FeNO value was compared among the three groups.Relationship between FeNO value and lung function, smoking history was investigated.Results FeNO value was significantly higher in the AECOPD group than in the healthy control group and the stable COPD group (P<0.05), but it showed no significant difference between the stable COPD group and the AECOPD group (P>0.05).FeNO value was significantly lower in patients with a history of smoking than those without (P<0.05).FeNO value was positively correlated with lung function (P<0.05).Conclusion FeNO value reflects the airway inflammation in COPD patients.It can be used to evaluate the severity during acute exacerbation period.Smoking can cause FeNO value decrease.
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