Objective To investigate the effect of serum thyroid hormone on the prognosis of patients with chronic obstructive pulmonary disease. Methods A retrospective study was conducted in 96 patients with AECOPD from July 2014 to July 2017. 96 healthy people at the same period were taken as the control group. Their serum thy-roid hormone was compared before and after treatment ( before discharge) . According to the patient' s respiratory ca-pacity, they were divided into the mild group and the middle-severe group. According to the patient' s condition, they were divided into the survival group and the death group. Their serum thyroid hormone levels were compared between the two groups. Results The levels of TT4, FT4, TT3 and FT3 in the study group were significantly higher than those in the control group (P<0. 05). There was no significant difference in TSH content between the study group and the control group. The levels of TT4, FT4, TT3 and FT3 were significantly lower after treatment in the study group, but there was no significant difference in TSH content before and after treatment in the study group. The levels of TT3 and FT3 in the mild hypoxia group were significantly higher than those in the moderate to severe hypoxia group. There was no significant difference in TT4, FT4 and TSH contents between the mild hypoxia group and the moderate to severe hypoxia group. The TT3 and FT3 contents of the survival group were significantly higher than those of the death group, and the difference was statistically significant. There was no significant difference in TT4, FT4 and TSH levels between the survival group and the death group. Conclusion There is a certain relationship between serum thyroid hormone levels and chronic obstructive pulmonary disease in patients with AECOPD. The levels of TT3 and FT3 are closely related with the severity of COPD, which is beneficial to the prognosis of patients.%目的 探讨血清甲状腺激素对慢性阻塞性肺疾病加重期(AECOPD)患者预后影响.方法 回顾性分析2014年7月-2017年7月在本院住院治疗的慢性阻塞性肺疾病急性加重患者96例为研究组,选择同期在本院进行健康体检者96例为对照组,比较研究组和对照组患者治疗前血清甲状腺激素,比较研究组患者治疗前和治疗后(出院前)的血清甲状腺激素,根据患者的呼吸能力,根据患者的动脉血氧分压将患者分为轻度缺氧组和中重度缺氧组比较两组患者的血清甲状腺激素水平,根据患者治疗的情况将患者分为存活组和死亡组,比较两组患者的血清甲状腺激素水平.结果 研究组患者的TT4、FT4、TT3、FT3含量水平显著高于对照组,差异具有统计学意义,研究组和对照组患者的TSH含量的差异无统计学意义.研究组患者治疗前的TT4、FT4、TT3、FT3含量水平显著低于研究组治疗后,研究组患者治疗前和治疗后的TSH含量的差异无统计学意义.轻度缺氧组患者的TT3、FT3含量显著高于中重度缺氧组,差异具有统计学意义,轻度缺氧组患者与中重度缺氧组患者的TT4、FT4、TSH含量的差异无统计学意义.存活组患者的TT3、FT3含量显著高于死亡组,差异具有统计学意义,存活组和死亡组患者的TT4、FT4、TSH含量的差异无统计学意义.结论 血清甲状腺激素水平与慢性阻塞性肺疾病加重期患者的病情存在一定的联系,TT3、FT3含量与慢性阻塞性肺疾病加重期患者的预后存在密切联系,有利于患者预后的评估.
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