CLINICAL PROFILES AND PROGNOSIS OF PATIENTS WITHSYMPTOMATIC AND ASYMPTOMATIC BRUGADA SYNDROME FROM A MULTI-CENTER STUDY IN JAPAN

摘要

Clinical profiles of patients with Brugada syndrome (BS) and BS type ECG (BSECG) in Japan remain to be elucidated. The object of this study is to clarify the clinical profiles and prognosis of those patients. Method and Results Clinical and follow up data were collected from 395 patients with BS and BSECG (373 male, 22 females, age 51+-12); 70 patients who survived sudden death(Group A), 68 patients who had a history of syncope(Group B) and 257 patients were asymptomatic before recognition of BSECG (Group C). Family history of BS or BSECG was observed in 14.3%, 8.8%, and 6.0%(p=ns) , the incidence of atrial Fibrillation was 37.1%, 19.1% and 13.2%(p<0.0l), programmed electrical stimulation induced ventricular fibrillation in 60%(36/60), 79%(45/57) and 52%(59/114)(p=ns), and new arrhythmic events during prospectively follow-up 12 months occurred in 24%(16/67), 3%(2/66), and 0.9%(2/229)(p<0.01) of patients in group A, group B, and group C, respectively. Conclusion Group A patients showed the same high recurrence rate of ventricular arrhythmias, but group B and C patients were different in its prognosis and showed better prognosis compared with the previous report.