阿立哌唑对抗精神病药物致女性精神分裂症患者高催乳素血症的影响

摘要

Objective To explore the effects of aripiprazole on antipsychotic-in-duced hyperprolactinemia (AIH) of female patients with schizophrenia .Methods Forty-eight AIH female schizophrenia patients were plus small-dose aripiprazole on the basis of maintaining original treatment with antipsychotic drugs for 8 weeks .Mental symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) ,changes of patients’ serum prolactin levels detected .Results There were significant differences in the PANSS and TESS scores between post-and pre-treatment (P>0 .05) ,serum prolatin levels lowered continuously and had very significant differences at the end of the 4th and 8th week from pretreatment ( t =4 .12 ,6 .32 ;P<0 .01) .Conclusion Aripiprazole could improve the AIH of female schizophrenia patients notably ,has an evident effect ,and doesn’t increase adverse reactions .%目的：探讨阿立哌唑对抗精神病药物所致女性精神分裂症患者高催乳素血症的影响。方法对48例抗精神病药物所致高催乳素血症的女性精神分裂症患者，在维持原用抗精神病药物治疗的基础上联合小剂量阿立哌唑治疗，观察8周。采用阳性与阴性症状量表评定精神症状，副反应量表评定不良反应，同时检测患者血清催乳素水平的变化。结果本组患者治疗后阳性与阴性症状量表及副反应量表评分与治疗前比较差异均无显著性（P＞0．05），而血清催乳素水平较治疗前呈持续性下降，治疗第4周、8周末与治疗前比较差异均有极显著性（ t ＝4．12、6．32，P＜0．01）。结论阿立哌唑能显著改善抗精神病药物所致女性精神分裂症患者的高催乳素血症，疗效显著，不增加不良反应。