目的：探讨阿托伐他汀钙联合羟苯磺酸钙治疗糖尿病下肢动脉硬化闭塞症的临床疗效。方法将30例2型糖尿病下肢动脉硬化闭塞症患者随机分为治疗组18例和对照组12例，两组均予以诺和灵30 R皮下注射治疗，治疗组在此基础上口服阿托伐他汀钙、羟苯磺酸钙治疗，观察16周。检测两组腓总神经感觉传导速度、踝臂指数、趾臂指数及血糖、血脂的变化。结果治疗后两组腓总神经感觉传导速度、踝臂指数、趾臂指数均较治疗前显著提高（P＜0．05或0．01），治疗组较对照组提高更显著（P＜0．01）；治疗组脉博波传导速度较治疗前显著下降（P＜0．01），对照组则无显著变化（P＞0．05）。治疗组总胆固醇、三酰甘油、低密度脂蛋白水平均较治疗前显著下降（P＜0．01），对照组虽较治疗前有所下降，但差异无显著性（P＞0．05）。结论阿托伐他汀钙联合羟苯磺酸钙治疗能有效改善糖尿病下肢动脉硬化闭塞症患者下肢缺血状况。%Objective To explore the efficacy of atorvastatin calcium plus calcium dobesilate in arterioscle‐rosis obliterans in lower extremity (AOLE) of diabetes mellitus (DM ) .Methods Thirty type 2 DM pa‐tients with AOLE were randomly assigned to treatment (n=18) and control group (n=12) ,both groups were treated with isophane protamine biosynthetic human insulin injection (pre‐mixed30R) ,on this basis treatment group took orally atorvastatin calcium plus calcium dobesilate foe 16 weeks .Changes of common peroneal nerve sensory conduction velocity (SCV) ,ankle‐brachial index (ABI) ,toe brachial index (TBI) , blood glucose and blood fat were detected .Results After treatment SCV ,ABI and TBI of both groups heightened more significantly compared with pretreatment (P<0 .05 or 0 .01) ,so did those in treatment than in control group (P<0 .01);pulse conduction velocity lowered more significantly in treatment (P<0 .01) and didn’t change notably in control group (P>0 .05) .Cholesterol total ,triacylglycerol and low density lipoprotein level lowered more significantly in treatment (P<0 .01) ,those did somewhat in control group ,but difference wasn’t significant (P>0 .05) .Conclusion Atorvastatin calcium plus calcium dobe‐silate could effectively improve lower limb ischemia status of DM patients with AOLE .
展开▼
