Objective To explore the efficacy and safety of Xiaofeng relieving itching particles (RIP) plus fexofenadine in the treatment of senile pruritus.Methods Ninety-six senile patients with skin pruritus were assigned to 3 groups of 32 ones each according to random table.Observation group was treated with Xiaofeng RIP plus fexofenadine, control Ⅰ with Xiaofeng RIP, and control Ⅱwith fexofendine for 4 weeks.Efficacies were decided according to clinical symptoms and adverse reactions compared.Results At the end of the 2nd week total effective rate was respectively 68.8% in observation, 37.5% in control Ⅰand 34.4% in control Ⅱgroup;at the end of the 4th week total effective rate was respectively 81.3% in observation, 46.9% in control Ⅰand 40.6% in control Ⅱgroup;at the ends of the 2nd and 4th end total effective rates were significantly higher in observation than in control Ⅰand Ⅱgroup (P<0.05).The 3 groups had no severe adverse reactions and the incidences no significant group differences (P>0.05).Conclusion Xiaofeng RIP combined with fexofenadine has an evident effect and higher safety in the treatment of senile skin pruritus.%目的 探讨消风止痒颗粒联合非索非那定片治疗老年性皮肤瘙痒症的临床疗效及安全性. 方法 将96例老年性皮肤瘙痒症患者按随机数字表法分为3组,每组32例.观察组给予消风止痒颗粒联合非索非那定治疗,对照Ⅰ组给予消风止痒颗粒治疗,对照Ⅱ组给予非索非那定治疗,观察4周.根据临床症状判定疗效,并比较不良反应发生状况.结果 治疗2周末,观察组总有效率为68.8%,对照Ⅰ组为37.5%,对照Ⅱ组为34.4%;治疗4周末,观察组总有效率为81.3%,对照Ⅰ组为46.9%,对照Ⅱ组为40.6%;治疗2周、4周末,观察组总有效率均显著高于对照Ⅰ组和对照Ⅱ组(P<0.05).3组均未出现严重不良反应,不良反应发生率比较差异无统计学意义(P>0.05).结论 消风止痒颗粒联合非索非那定治疗老年性皮肤瘙痒症疗效显著,安全性高.
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