阿立哌唑治疗抗精神病药所致闭经的精神分裂症对照研究

摘要

目的:探讨阿立哌唑对抗精神病药所致闭经的精神分裂症患者的影响.方法:69例抗精神病药引起闭经的女性精神分裂症患者,随机分为A组(单用阿立哌唑治疗)34例和B组(用其他抗精神病药联合中药血府逐瘀汤治疗)35例,观察疗程3个月.于治疗前、治疗后1、2、3个月测定血清催乳素浓度,并评定闭经的疗效.结果:治疗后两组血清催乳素浓度均较治疗前降低;以A组血清催乳素浓度(15.21±6.17)μg/L显著低于B组(85.91±24.86)μg/L(t=-15.870,P=0.000);A组闭经治疗总有效率100%显著高于B组84.85%(χ2=67.00,P=0.000).结论:阿立哌唑治疗因抗精神病药所致闭经的精神分裂症患者安全、有效.%Objective:To study the clinical effect of aripiprazole in the treatment of schizophrenic patients with amenorrhea induced by antipsychotics.Method:69 female schizophrenic patients with amenorrhea induced by antipsychotics were randomly divided into two groups, group A (n =34, treated by aripiprazole) and group B (n = 35, treated by other antipsychotics combined with traditional Chinese medicine Xuefuzhuyu soup) ,for 3 months treatment.The serum level of prolactin was measured before and after 1,2 and 3 months treatment.The efficacy on amenorrhea was evaluated.Results:The serum level of prolactin decreased in both group after treatment, with significant decrease in group A compared with that in group B[(15.21 ± 6.17 ) μg/L vs.( 85.91 ± 24.86) μg/L( t = - 15.870, P = 0.000).The total treatment response rate for amenorrhea was 100％ in patients of group A, significanfiy higher than that 84.85％ in group B (x2 = 67.00, P=0.000).Conclusion:Aripiprazole can treat amenorrhea induced by antipsychotics in patients with schizophrenia efficaciously and safely.