Objective:To investigate the maintenance medicine-taking in patients with schizophrenia disrncharged within 2 years and study the related influence factors. Method:We followed-up 293 discharged parntients with schizophrenia to investigate the statue of discontinuation of antipsychotics use. Time to treatment disrncontinuation (TTD) was used as an index to explore the likely influence factors for maintenance medicine-takrning. Results :129 and 175 discharged patients within 1 and 2 years, respectively,discontinue to take antipsyrnchotics with the incidence of medicine discontinuation 44.79％ (95％ CI = 39.05 ～ 50. 53％ ) and 60.76％rn(95％ CI = 55.12％ ～ 66.40％ ). The related influence factors for TTD included the duration of illness,clozaprnine-taking,the total score of positive and negative syndrome scale (PANSS) and globe assessment scale (GAS)rnat the time of discharge, financial capability,family custody and community support (P ＜ 0.05 or P ＜ 0. 001 ).rn Conclusion:The patients with schizophrenia discharged within 2 years had higher incidence of medicine disrncontinuation. The benign factors for maintenance medicine-taking were the improvement in psychotic symptoms rnand social functioning and the better financial capability as well as better community support. However,the marnintenance duration of medicine-taking was shorter in patients with non-family custody and poor medicine complirnance.%目的:调查精神分裂症患者出院后2年内维持服药情况,探讨影响维持服药的各种因素.方法:随访293例精神分裂症患者出院后停药情况,以停药前服药时间为指标探讨可能影响维持服药的因素.结果:出院后1年内停药129例,停药率为44.79%(95%CI:39.05～50.53%),2年内总停药175例,停药率为60.76%(95%CI:55.12%～66.40%).影响停药前服药时间的相关因素有:病程的长短、是否服用氯氮平、出院时阳性与阴性症状量表(PANSS)及大体评定量表(GAS)评分的高低、支付能力的好坏、有无亲人监护及社区支持有关(P<0.05或P<0.001).结论:2年内精神分裂症患者有较高的停药率.症状的改善、社会功能的改善、支付能力好及有社区支持均有利于维持服药;而非亲人监护、依从性差,则维持服药的时间较短
展开▼
