高频重复经颅磁刺激联合文拉法辛治疗抑郁症的早期疗效

摘要

目的:探讨高频重复经颅磁刺激(20 Hz rTMS)联合文拉法辛治疗抑郁症的早期疗效与安全性. 方法:将40例抑郁症患者随机分为研究组(n=20例)和对照组(n=20例).研究组给予20HzrTMS联合文拉法辛治疗,对照组单用文拉法辛联合假rTMS治疗.观察6周.两组分别于治疗前和治疗2、4、6周采用汉密尔顿抑郁量表(HAMD)评定疗效；采用治疗中出现的症状量表(TESS)评定不良反应. 结果:两组治疗后HAMD评分均有显著下降(P＜0.05)；以研究组在治疗2、4周时降分显著(P＜0.05).两组间部分不良反应发生率存在统计学意义(P＜0.05). 结论:高频重复经颅磁刺激联合文拉法辛治疗抑郁症早期疗效优于单一用药,不良反应发生率较低.%Objective .To explore the difference of effects and security between patients treated with single venlafaxine and venlafaxine combined with high frequency repetitive transcranial magnetic stimulation (20 HzrTMS). Method:40 patients met with Chinese classification and diagnostic criteria of mental disorders (Version 3) were grouped into experimental group (20 patients, treated with venlafaxine combined rTMS) and control group (20 patients, treated with venlafaxine) randomly. All patients were given at least one 6-weelc treatment. Measurements including the Hamilton depression scale ( HAMD) for therapeutic effects and the treatment emergent side-effect scale (TESS) for side-effects at before and after 2,4,6 weeks. Results: For HAMD scores, both of groups showed a significant reduction (P < 0. 05 ). And the reduction of experimental group was higher than that of control group (P < 0.05) at week 2 and 4. There is difference on the side-effects between two group some adverse reactions (P < 0.05). Conclusion: rTMS was found to be effective as add-on to venlafaxine and remission gastrointestinal tract irritation.