酒精所致精神障碍患者的P300、智能损害及相关因素研究

摘要

Objective: To explore the event-related potential P300, intellectual impairment and correlated factors in mental disorder due to use of alcohol. Method: Thirty patients with mental disorders due to use of alcohol and thirty healthy controls were involved, the event-related potential P300 and Wechsler intelligence test were used to assess the brain cognitive function. Logistic regression was used to analyse the correlative factors. Results:P300 latency of study group(374. 90 ±63. 08) ms was longer than the control group(305;40 ± 10. 84) ms,There were significant differences in both study group and control group (P =0. 000). Study group amplitude (5. 62 ±2. 42) μV was lower than the control group(7. 50 ±0. 76) μV, difference was significant (P = 0.000). Study group showed lower verbal,performance and total intellegence quotient [ (85. 60 ±10. 82) ,, (86.60 ±12.59), (82. 27 ±11.52), respectively] than the control group [( 103. 30 ± 3. 40) , (99. 90 ± 2.74) ,(101. 16 ±2.57) .respectively] ,the difference was significant (P=0.000). Partial correlation analysis result showed that the longer P300 latency was related with the duration of alcohol dependence controling for av erage daily alcohol consumption factors (r = 0. 577, P =0.001). The full intellegence quotient was related with duration of alcohol dependence controling for average daily alcohol consumption factors (r = - 0. 582 ,P = 0.001). Conclusion: The event-related potential P300 latency is longer and the amplitude is lower in mental disorders due to use of alcohol compared with healthy controls. The cognitive impairment is evident in patients with mental disorders due to use of alcohol. The mainly related factor to cognitive impairment is duration of alco hol dependence.%目的:探讨酒精所致精神障碍患者的P300、智能损害及相关因素.方法:对顺序住院30例酒精所致精神障碍患者和30名健康者分别进行P300和韦氏智力测试,比较测试结果并对影响因素进行分析.结果:研究组P300潜伏期(374.90±63.08)ms长于对照组(305.40±10.84)ms,差异有显著性(P =0.000).研究组波幅(5.62 ±2.42)μV低于对照组(7.50 ±0.76)μV,差异有显著性(P=0.000).研究组语言智商、操作智商、总智商分别为(85.60±10.82)分、(86.60±12.59)分、(82.27±11.52)分,低于对照组分别为(103.30±3.40)分、(99.90±2.74)分、(101.16±2.57)分,差异有显著性(P=0.000).偏相关分析:控制平均日饮酒量因素P300潜伏期与酒依赖病程相关(r=0.577,P=0.001).总智商与酒依赖病程相关(r=-0.582,P=0.001).结论:酒精所致精神障碍患者的P300潜伏期明显延长,波幅明显降低,智力明显下降,认知损害明显.认知损害程度主要与酒依赖病程有关.