抑郁症患者治疗前后血浆皮质醇水平的变化

摘要

Objective:To explore the change of plasma cortisol level in patients with depression before and after treatment.Method:One hundred and sixty depressed patients were treated with antidepressant drugs for 6 weeks.Before and after treatment,they were evaluated by Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) ;and the plasma cortisol level was detected.Results:Before and after treatment,the total scores of HAMD were (24.98 ±5.10) and (7.57 ±5.61); the total scores of HAMA were (20.62 ± 6.90) and (6.21 ± 5.17) ; the plasma cortisol levels were (407.34 ± 144.29) nmol/L and (354.64 ± 137.13)nmol/L respectively.After treatment the total scores of HAMD and HAMA and the plasma cortisol level were significantly decreased than those at before treatment (all P ＜ 0.001).The plasma cortisol level between genders was no significant difference (P ＞ 0.05).There was no correlation between the change value of plasma cortisol level and the reducing ratio of HAMD or HAMA (r =0.084,r =0.049 ;all P ＞ 0.05).Conclusion:Antidepressant drugs can decrease the plasma cortisol level in patients with depression.%目的:探讨抑郁症患者治疗前后血浆皮质醇水平的变化. 方法:对160例抑郁症患者给予抗抑郁药治疗6周,分别于治疗前及治疗后进行汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评估及血浆皮质醇水平检测. 结果:本组治疗前后HAMD总分分别为(24.98 ±5.10)和(7.57±5.61);HAMA总分分别为(20.62±6.90)和(6.21±5.17);血浆皮质醇水平分别为(407.34±144.29) nmol/L和(354.64±137.13) nmol/L.治疗后HAMD总分、HAMA总分及血浆皮质醇水平较治疗前明显下降(P均＜0.001);不同性别间血浆皮质醇水平差异无统计学意义(P＞0.05);血浆皮质醇变化值与HAMD、HAMA减分率不相关(r=0.084,r =0.049;P均＞0.05). 结论:抗抑郁药物治疗可显著降低抑郁症患者血浆皮质醇水平.