2~3岁孤独谱系障碍儿童尾状核体积与重复刻板行为的关系

摘要

Objective:To explore the caudate nucleus volume between the autism spectrum disorder (ASD)and developmental delay(DD)groups,and determine the relationship between caudate nucleus volume and restricted,repetitive behavior(RRB)in 2-to 3-year old children with ASD. Method:Caudate nucleus volume,quantified by ITK-SNAP,was compared between 66 children with ASD and 36 age,gender and intelli-gence-matched control children with DD aged 2-to 3-years. The relationship between caudate nucleus volume and RRB scores of autism diagnostic interview-revised(ADI-R)was analyzed. Results:The volumes of left (P = 0. 002),right(P ﹤ 0. 001)and total(P = 0. 001)caudate nucleus were significantly larger in the ASD group compared to the DD group. In ASD group,left(r = 0. 329,P = 0. 004)and total(r = 0. 317,P = 0. 013) caudate nucleus volumes were significantly associated with lower order RRB scores. Conclusion:The caudate nucleus volume in 2 to 3 year old children with ASD is incresed and correlated with lower order repetitive behaviors.%目的：对比2~3岁孤独谱系障碍（ASD）与发育迟缓（DD）儿童尾状核体积的差异，并探讨尾状核体积与重复刻板行为严重程度的关系。方法：使用 ITK-SNAP 软件分别计算并比较66例 ASD儿童（ASD 组）和36例年龄、性别、智商与之相匹配的 DD 儿童（DD 组）的尾状核体积，并与由孤独症诊断访谈量表-修订版（ADI-R）所得重复刻板行为分数进行相关分析。结果：ASD 组尾状核左侧（P ＝0.002）、右侧（ P ﹤0.001）以及总体积（ P ＝0.001）较 DD 组显著增大；尾状核左侧（ r ＝0.329，P ＝0.004）、总体积（r ＝0.317，P ＝0.013）与 ADI-R 低水平重复刻板行为分呈显著正相关。结论：2~3岁的 ASD 儿童已表现出尾状核体积的异常增大，且与低水平的重复刻板行为有相关。