迟发性运动障碍患者血清铁调素、铁蛋白水平的研究

摘要

Objective:To explore the serum levels of hepcidin(Hep),ferritin( Fn)in schizophrenics with tardive dyskinesia(TD)as well as the relationship between iron metabolic status and TD. Method:Ser-um levels of Hep and Fn in 30 schizophrenics with TD(TD group),41 schizophrenics without TD(non-TD group)and 41 normal subjects(normal control group)were measured by enzyme immunoassay and chemilumi-nescence,respectively. Severity of TD was assessed with the abnormal involuntary movement scale(AIMS). Cor-relation of score of AIMS and serum level of Hep,Fn were analyzed. Results:Serum level of Hep in TD group was significantly lower than that in non-TD group and normal control group(Z = - 2. 99,Z = - 3. 62,all P <0. 01),while no difference was shown between non-TD group and normal control group(Z = 1. 22,P > 0. 05). Serum level of Fn in TD group was higher than that in non-TD group and normal control group(Z = 2. 00,Z =2. 39,all P < 0. 05),there was also no significant difference in serum level of Fn between non-TD group and normal control group(Z = - 0. 70,P > 0. 05). In TD group,serum level of Hep was negatively correlated with serum level of Fn(r = - 0. 396,P < 0. 05),no correlation existed between score of AIMS and serum level of Hep or Fn(r = - 0. 052,r = 0. 14;all P > 0. 05). Conclusion:TD patients have abnormal iron metabolic pro-tein. Iron metabolic disorder may be involved in the pathophysiological process of TD.%目的：探讨伴有迟发性运动障碍（TD）的精神分裂症患者血清铁调素（Hep）、铁蛋白（Fn）水平，以及铁代谢状况与 TD 的关系。方法：采用酶免疫法及化学发光法测定30例伴 TD 的精神分裂症患者（TD 组）、41例不伴 TD 的精神分裂症患者（非 TD 组）及41名正常人（正常对照组）血清 Hep、Fn 水平；用异常不自主运动量表（AIMS）评估患者 TD 的严重程度及其与血清 Hep、Fn 水平的相关性。结果：TD 组血清 Hep 水平低于非 TD 组及正常对照组（Z =-2.99，Z =-3.62；P 均<0.01），非 TD 组与正常对照组之间 Hep 水平差异无统计学意义（Z =1.22，P >0.05）；TD 组血清 Fn 水平高于非 TD 组及正常对照组（Z =2.00，Z =2.39；P 均<0.05），非 TD 组与正常对照组之间 Fn 水平差异无统计学意义（Z =-0.70，P >0.05）。TD 组血清 Hep 水平与 Fn 水平呈负相关（r =-0.396，P <0.05），AIMS 评分与血清 Hep 及 Fn 水平无相关性（r =-0.052，r =0.14；P 均>0.05）。结论：TD 患者存在铁代谢蛋白异常，铁代谢障碍可能参与了 TD 的病理生理过程。