目的 探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患儿血浆C-反应蛋白(CRP)的变化.方法 检测40例OSAHS患儿及27例健康对照儿童的血浆CRP与血生化指标,完成多导睡眠监测(PSG).结果 中重度OSAHS组的血浆CRP较对照组和轻度OSAHS组明显增高,并且CRP与呼吸暂停低通气指数(AHI)呈正相关(r=0.824,P＜0.01),与最低指脉氧饱和度(SaO2)呈负相关(r=-0.802,P＜0.01).CRP值升高的患儿中,出现白天嗜睡和(或)学习障碍者占82.3%,而CRP正常的儿童,有此症状者仅占46.0%.结论 中重度OSAHS患儿CRP增高,并且与AHI和SaO2相关联.CRP增高在白天嗜睡和(或)学习障碍的儿童表现更为明显.%Objectives To explore the C-reactive protein (CRP) level in children with obstructive sleep apnea hypopnea syndrome ( OSAHS ). Methods Totally 40 OSAHS patients and 27 healthy children were recruited for this study. OSAHS kids were divided into three groups according to the severity of the condition. The result of plasma CRP、lipid profile、 polysomnography of OSAHS patients were compared with that of healthy children, and within the three groups. Results Log plasma CRP levels were significantly higher in the moderate-severe group ( obstructive apnea/hypopnea index [AHI] of ≥ 10) than that of the nild OSAHS group ( AHI of ＞ 5 and ＜ 10) and the control group(AHI of ≤ 5 ); Significant positive corelations were found between logCRP levels and AHI (r= 0.824, P ＜ 0.01 ),whereas an inverse correlation was seen between the nadir arterial oxygen saturation and logCRP levels (r= -0.804,P ＜ 0.01); Moreover, 82.3％ of the children with elevated logCRP levels reported excessive daytime sleepiness and/or learning problems, compared with 46％ of children with normal logCRP levels. Conclusions Children with moderatesevere OSAHS are associated with increasing levels of CRP, which is correlated with AHI, arterial oxygen saturation nadir. These changes were particularly prominent among children with sleepy and/or had learning problems.( J Clin Pediatr,2011,29( 2 ):142-144 )
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