2821例糖尿病患者发生糖尿病视网膜病变相关危险因素分析

摘要

Objective To prevent and treat early diabetic retinopathy ( DR ) by analyzing its relevant risk factors.Methods 2821 patients with diabetes mellitus underwent comprehensive ocular examination, blood inspection, microalbumin uria ( MAU ) examination, blood pressure measure, body mass index ( BMI ) examination, and duration of diabetes enquiry. Blood inspection includes fasting blood-glucose, triglyceride, and HbAlc. SPSS13.0 was applied to make statistical analysis and data comparison was done by patient x2test. Logistic regression, including single factor logistic regression and multiple factor logistic regression, was applied to examine the correlation tests between diabetic retinopathy ( DR ) and its influencing factors. Results Diabetic retinopathy is clearly associated with gender, age, duration of diabetes, fasting blood-glucose, HbAlc, bodymass index( BMI ), blood pressure, microalbumin uria, and triglyceride ( P ＜0.05 ). The duration of diabetes, fasting blood-glucose, HbA1c, microalbumin uria , and triglyceride are the independent risk factors of DR. Conclusion Diabetic retinopathy ( DR ) is the result of multi-factors. Therefore, special attention should be paid to the prevention of the risk factors so as to decrease the incidence of diabetic retinopathy.%目的 通过分析糖尿病患者发生糖尿病视网膜病变(DR)的相关危险因素,以达到预防和治疗早期DR的目的 .方法 对2821例糖尿病患者进行全面眼科检查,抽血检测:空腹血糖、甘油三脂、糖化血红蛋白;尿微量蛋白检验;测量血压;体重指数检查;询问病程.运用SPSS13.0软件进行统计分析,计数资料比较采用卡方χ2检验;DR与各种影响因素间相关性检验用Logistic回归分析,分别进行单因素和多因素回归分析.结果 DR的发生与性别、年龄、糖尿病病程、空腹血糖、糖化血红蛋白、体重指数、血压、甘油三脂、尿微量蛋白存在明显相关性(P<0.05);糖尿病病程、空腹血糖、糖化血红蛋白、甘油三脂、尿微量蛋白是DR的独立危险因素.结论 DR 的发病是多因素作用的结果,应重视并加强糖尿病危险因素的防治,降低DR 的发病率.