听觉事件相关电位对轻度认知功能障碍的诊断价值

摘要

目的 研究听觉事件相关电位(AERPs)对轻度认知功能障碍(MCI)的诊断价值.方法 对34例MCI患者、18例Alzheimer病(AD)患者和34名正常对照(NC)者进行AERPs和神经心理学量表检查.并对MCI患者AERPs与神经心理学量表结果的相关性进行分析.结果 与AD组比较,MCI组和NC组AERPs的计数准确率显著升高,反应时间(RT)显著缩短(均P＜0.01).MCI组与NC组AERPs计数的准确率与RT差异均无统计学意义.MCI组的P50波幅明显高于AD组和NC组(P ＜0.05～0.01).与NC组比较,MCI组和AD组的P300潜伏期明显延长、波幅显著降低(P ＜0.05 ～0.01).与AD组比较,MCI组的P300潜伏期明显缩短、波幅明显增高(P ＜0.05～0.01).3组间P50潜伏期及N100、P200、N200的波幅、潜伏期比较,差异无统计学意义.Pearson相关分析显示,各量表的记忆评分与P50波幅、P300潜伏期呈负相关(均P＜0.01).结论 MCI患者的AERPs明显异常,并且与正常老年人及AD患者均有不同的特点,可作为MCI诊断的一项参考指标.%Objective To investigate the diagnostic value of auditory event-related potentials (AERPs) on mild cognitive impairment (MCI).Methods Thirty-four MCI patients,18 Alzheimer's disease (AD) patients and 34 normal controls (NC) were examined by AERPs and tested by neuropsychological scales,and the correlation of AERPs and neuropsychological scales in MCI patients were ananlyzed.Results Compared with AD group,target stimuli accurate counting rate of AERPs in MCI group and NC group was significantly increased,and reaction time (RT) was significantly shorter (all P ＜0.01).There was no statistical significance of target stimuli accurate counting rate and RT of AERPs between MCI group and NC group.The amplitude of P50 in MCI group was significantly higher than those in AD group and NC group (P ＜0.05-0.01).Compared with NC group,the latency period of P300 in MCI group and AD group were significantly longer,amplitude of P300 were significantly decreased (P ＜ 0.05-0.01).Compared with AD group,the latency period of P300 in MCI group was significantly shorter,amplitude of P300 was significantly increased (P ＜ 0.05-0.01).The differences amplitude of P50,amplitude and latency period of N100,P200,N200 had no statistical significance among 3 groups.The Pearson correlation analysis showed that the memory scores of all scales were negatively correlated with the latency period of P50 and amplitude of P300 (all P ＜0.01).Conclusion AERPs of MCI patients are obviously abnormal,and the abnormal characteristics are different from normal elderly and AD patients.It can be used as a reference index in MCI diagnosis.