Objective To investigate influnce of obstructive sleep apnea hypopnea syndrome (OSAHS) to the levels of serum uric acid and blood lipid. Method The sleep parameter was perfomed by overnight polysomnography (PSG) in OSAHS group (158 cases) and control group (75 cases). Based on the results of the apnea-hypopnea index (AHI) , OSAHS group were divided into mild subgroup, moderate subgroup and severe subgroup. To compute body mass index (BMI) , the persons in the two groups were divided into fat subgroup and non-fat subgroup based on BMI. The levels of serum UA and blood lipid were detected, and the results were compared. The correlation analysis was performed between the levels of serum uric acid with PSG. Results Compared with control group, BMI, AHI, oxygen desaturation index ( ODI) , percentage of oxygen saturation < 90% of total recording time ( TS90% ) , respiration relevant microarousal, longest time of apnea and hypopnea, the level of serum UA, triacylglycerol, low density lipoprotein in OSAHS group were significantly higher, and lowest nocturnal oxygen saturation ( L-SaO2 ) , average oxyhemoglobin saturation (M-SaO2) and the level of high density lipoprotein (HDL) were significantly lower (P <0. 05 - 0. 01 ). Significant statistics differences were found of AHI, ODI, L-SaO2, the respiration relevant microarousal, the longest time of hypopnea in mild, moderate, severe subgroup compared in each two subgroups (P <0. 05 -0. 01 ). Compared with mild subgroup, TS90% , the level of serum uric acid in severe subgroup were significantly higher, and M-SaO2 and the level of HDL were significantly lower (all P <0. 01 ). The level of serum uric acid in OSAHS no-fat subgroup was significantly higher than control no-fat subgroup (P < 0. 01 ). Correlation analysis showed that there were positive correlation between the level of uric acid with AHI, TS90% , respiration relevant microarousal ( r = 0. 198 , r = 0. 289, r = 0. 245 ; P < 0. 05 - 0. 01 ). Conclusion The influnce on serum uric acid and blood lipid metabolism are aggravated with OSAHS condition.%目的 探讨阻塞性睡眠呼吸暂停综合征(OSAHS)对血清尿酸(UA)及血脂水平的影响.方法 应用多导睡眠监测(PSG)记录OSAHS组(158例)及对照组(75例)患者的睡眠参数,并根据睡眠呼吸暂停低通气指数(AHI)将OSAHS组分为轻度、中度和重度亚组.计算两组体质量指数(BMI),并分别将其分为肥胖亚组及非肥胖亚组.检测各组血清UA及血脂水平并比较.并将血UA水平与PSG指标进行相关性分析.结果 与对照组比较,OSAHS组BMI、AHI、氧减饱和指数(ODI)、血氧饱和度小于90％的比例(TS90％)、呼吸相关微觉醒、最长呼吸暂停时间和最长低通气时间及血清UA、三酰甘油、低密度脂蛋白水平均显著升高,夜间最低血氧饱和度(L-SaO2)、平均血氧饱和度(M-SaO2)及高密度脂蛋白水平显著降低(P＜0.05 ～0.01).AHI、ODI、L-SaO2、呼吸相关微觉醒、最长呼吸暂停时间在轻度、中度、重度3个亚组中两两比较差异均有统计学意义(P ＜0.05 ～0.01).与轻度亚组比较,重度亚组TS90％、UA水平显著增加,M-SaO2、高密度脂蛋白水平显著降低(均P＜0.01).OSAHS非肥胖亚组的血清UA水平较对照组非肥胖亚组显著升高(P＜0.01).Pearson相关性分析显示,血清UA水平与AHI、TS90％、呼吸相关微觉醒呈正相关(r=0.198,r=0.289,r=0.245;P ＜0.05～0.01).结论 OSAHS对血UA及血脂代谢的影响随病情而加重.
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