目的 探讨进展性脑梗死患者危险因素及血清白介素-1β(IL-1β)、白介素-6(IL-6)水平.方法 入选患者为本院帐治的急性期脑梗死患者80例,包括非进展性脑梗死患者33例(非进展组)和进展性脑梗死患者47例(进展组).另选取同期来本院健康体检中心体检的40例患者作为对照组.检测各组患者生化指标；酶联免疫吸附法(Elisa)检测患者血清IL-1β、IL-6水平.结果 进展组患者空腹血糖(GLU)、血浆纤维蛋白原(FIB)、血清同型半胱氨酸(Hcy)水平明显高于非进展组.进展组和非进展组患者血清IL-1β、IL-6水平明显高于对照组.进展组患者血清IL-1β、IL-6水平明显高于非进展组、进展组计算机断层扫描(CT)早期异常表现发生率、大面积脑梗死发生率均明显高于非进展组.结论 高血糖、高纤维蛋白原血症、高同型半胱氨酸血症为进展性脑梗死的危险因素.血清IL-1β、IL-6水平对进展性脑梗死发生有早期预警意义.%Objective To investigate the risk factors and serum IL-1β, IL-6 level in progressive cerebral infarction patients. Methods Eighty patients with acute cerebral infarction, including non-progressive cerebral infarction (n = 33, non-progressive group) and patients with progressive cerebral infarction (n = 47, progressive group). The other 40 patients who came to our physical examination center were selected as a control group. We detected the group of patients with biochemical indicators, Elisa assay of serum IL-1β, IL-6 levels. Results In the progressive group, the level of GLU, FIB, Hcy was significantly higher than the non-progressive group. Serum IL-1β, IL-6 levels in the progressive group were significantly higher than those in the non-progressive group. Advanced levels of serum IL-1β, IL-6 levels were significantly higher than in the non-progressive group. The early CT abnormalities and the incidence of massive cerebral infarction in the progressive group were significantly higher than those in the non-progressive group. Conclusion Hyperglycemia hyperfibrinogenemia and high hyperhomocysteinemia as risk factors for progressive cerebral infarction, serum IL-1β, and IL-6 levels have early warning significance for progressive cerebral infarction.
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