经皮内镜下胃造瘘术肠内营养治疗对鼻咽癌放疗患者的临床疗效

摘要

Objective To explore the effect of enternal nutrition on the radiotherapy of na-sopharyngeal carcinoma patients after percutaneous endoscopic gastrostomy(PEG).Methods 31 nasopharyngeal carcinoma patients were the research objects in the research.There were 12 patients with enteral nutrition therapy and 19 patients with parenteral nutrition therapy.Body mass index (BMI),hemoglobin (Hb),serum albumin protein (ALB),serum total protein (TP)and lympho-cyte count (LYM),PS score and complications after radiotherapy with two methods were com-pared.Results The difference was statistically significant in total protein and albumin in the com-parison group before and after radiotherapy.Intestinal serum,hemoglobin,body mass index , lymph node cell count,PS score remained stable during radiotherapy in the enternal group;Body mass index,PS assessment decreased serum total protein,albumin,hemoglobin,body mass index, lymph node cell counts remained stable in the parenteral group before and after radiotherapy.There was no patients with intestinal complications in enternal group and 7 patients had complications in the parenteral group.Conclusion PEG is reasonable and effective method for nasopharyngeal carci-noma radiotherapy patients combined with oral mucositis.Nutritional support enjoys lower price and less complications,so it is worthy of clinical application.%目的：探讨经皮内镜下胃造瘘（PEG）肠内营养治疗对鼻咽癌放疗患者的疗效。方法选取本院2010年9月-2013年8月经病理确诊的鼻咽癌放疗患者31例，选择鼻咽癌放疗予肠内营养治疗者12例和肠外营养治疗者19例，比较2种方法对鼻咽癌放疗期间2组患者体质量指数（BMI）、血红蛋白（Hb）、血清白蛋白（ALB）、血清总蛋白（TP）及淋巴细胞计数（LYM）、PS 评分、并发症在放疗前后的变化。结果肠内组放疗前后患者的 TP、ALB 差异有统计学意义，Hb、BMI、LYM、PS评分在放疗期间保持稳定；肠外组放疗前后患者 BMI、PS 评估下降，TP、ALB、Hb、LYM 保持稳定。肠内组无一例发生相关并发症，肠外组有7例出现相关并发症。结论 PEG 是鼻咽癌放疗合并口腔黏膜炎患者的合理有效的营养支持方法，其价格低廉、并发症少、符合正常肠道功能，值得临床推广应用。