血小板活化指标及脂代谢指标与妊娠高血压疾病的相关性

摘要

Objective To analyze the correlation between platelet activation indexes,lipid metabolism indexes and hypertensive disorder complicating pregnancy (HDCP).Methods A total of 273 cases with HDCP were divided into mild preeclampsia group (n =167) and severe preeclampsia group (n =110) according to the severity of the disease,and 100 healthy pregnant women were selected as control group.The blood platelet parameters and lipid metabolism parameters were detected by automatic blood cell analyzer,and platelet activation parameters were detected by ELISA.Resuits There were significant differences in platelet parameters (PLT,MPV,P-LCR and PDW),platelet activation indexes (PF4,β-TG,P-S) and lipid metabolism indicators (CHOL,TRIG,APOB,APOA,LDL-C) among three groups (P ＜ 0.05).Conclusion In the pregnant women with HDCP,the level of blood lipid metabolism indexes and platelet activation are abnormal.%目的 分析血小板活化指标及脂代谢指标与妊娠高血压疾病的相关性.方法 273例妊娠期高血压疾病孕妇根据病情分为轻度子痫前期亚组(n =167)、重度子痫前期亚组(n=110);另选取同时期健康孕妇100例作为对照组.采用全自动血细胞仪检测血小板参数及脂代谢指标,采用ELISA检测血小板活化指标.结果 3组各项血小板参数(PLT、MPV、PDW和P-LCR)、血小板活化指标(PF4、β-TG、P-S)及脂质代谢指标(CHOL、TRIG、LDL-C、APOB、APOA)比较,差异有统计学意义(P＜0.05).结论 妊娠期高血压孕妇存在血脂代谢水平异常、血小板过度活化等病理性状态.