过敏性哮喘青春期缓解者外周血IL-4、IL-5活性和IgE的变化

摘要

目的 阐明过敏性哮喘青春期缓解者血清IL-4及IL-5活性和IgE的变化。方法采用ELISA法检测IL-4、IL-5活性和IgE，分别对16例青春期缓解者(A组)，26例哮喘发作期(B组)及22例哮喘缓解期患者(C组)和20例正常人(D组)进行比较。结果 (1)青春期缓解者IL-5活性未显著升高，明显低于哮喘发作期患者(P＜0.01)和缓解期患者(P＜0.05)，与正常人比较差异无显著性(P＞0.05)。(2)青春期缓解者IL-4较哮喘发作期患者明显降低(P＜0.01)，与缓解期患者和正常人比较差异无显著性(P＞0.05)。(3)IgE浓度比发作期明显降低(P＜0.01)，与正常人比较差异无显著性(P＞0.05)，但还未明显低于哮喘缓解期患者(P＞0.05)。结论 过敏性哮喘青春期缓解者外周血IL-4、IL-5活性明显降低，IgE有一定程度下降，提示IL-4、IL-5、IgE在支气管哮喘发病机制上起着重要作用。%Objective To evaluate the activities of IL-4 and IL-5 and the serum IgE level in patients with allergic asthma remiting at puberty. Methods All subjects were divided into four group, including A(allergic asthma remiting at puberty), B(astb ma at stage of attack), C(asthma at stage of remission) and D(healthy subjects). The activities of IL-4, IL-5 and serum IgE levels in all subjects were measured by ELISA. Results (1) The activity of IL-5 in group A didn' t significantly increased, being significantly lower than that in group B( P＜0.01) and C( P＜0.05). There wasn't abvious difference between group A and D. (2)The activity of IL-4 in group A was significantly lower than that in group B( P＜0.01 ), being not significantly different from group C and D( P＞0.05). (3) Serum IgE level in group A was significantly lower than that in group B( P＜0.01), being not significantly different from group C and D( P＞0.05). Conclusion The activities of IL-4 and IL-5 in patients with allergic asthma remiting at puberty decreased significantly, and their serum IgE level decreased to a certain extent. These imply that IL-4, IL-5 and IgE play important roles in the mechanism of bronchial asthma.