Objective To evaluate the difference in the effect of early insulin pump intensive therapy on glucagon-like pepfide 1 ( GLP-1 ) of newly diagnosed type 2 diabetes. Methods 40 cases of newly diagnosed type 2 diabetes were randomly divided into two groups: continuous subcutaneous insulin infusion by insulin pump ( CSII) group and multiple subcutaneous insulin injection ( MSII) group, The changes in FPG、2hPG、 GLP-1 and C-P were compared between the two groups. Results FPG,2hPG were significantly decreased in both groups after treatment than before treatment, GLP-1 and C-P were significantly higher after treatment than before treatment, with a significant difference (P <0. 05). The changes in FPG、2hPGNGLP-land C-P of the CSII group were significantly higher than those of the MSII group(P <0. 05) . Conclusion Early insulin pump intensive therapy not only stabilizes the blood glucose,but also improves the b-cell function by increasing the level of GLP-1.%目的 探讨早期胰岛素泵强化治疗(CSII)对初发2型糖尿病患者胰高血糖素样肽-1(GLP-1)的影响.方法 将40例初发的2型糖尿病患者随机分为两组:胰岛素泵(CSII)组(20例)及常规皮下注射胰岛素(MSII)组(20例),比较两组患者治疗前后的空腹血糖(FPG)、2小时餐后血糖(2hPG)、GLP-1及C肽等各项指标变化.结果 CSII组和MSII组治疗前后FPG、2hPG水平均较治疗前明显下降,GLP-1及C肽较治疗前明显升高,差异均具有统计学意义(P＜0.05).CSII组FPG、2hPG、GLP-1及C肽治疗前后变化量明显高于MSII组(P＜0.05).结论 早期胰岛素泵强化治疗明显升高初发2型糖尿病患者GLP-1水平,在糖尿病早期,不仅可以有效控制血糖,还可以通过升高GLP-1改善胰岛功能,提高胰岛素敏感性.
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