老年人血红蛋白含量与血压水平的相关性研究

摘要

Objective To analyze the relationship between hemoglobin(Hb)level and blood pressure in elderly subjects.Methods This study was composed of 2 101 subjects of health examinations aged 60 years or above from Jiangchuan Community of Shanghai.The height,weight,waist(W),hip(H), blood pressure levels,Hb,blood lipid,fasting blood glucose(FBG),serum creatinine (Cr)and alanine transaminase(ALT)were measured.Subjects were classified into three groups according to blood pressure levels(normal blood pressure group:<120 /80 mmHg,n =477;prehypertension group:120 ~139 /80 ~89 mmHg,n =773;hypertension group:≥140 /90 mmHg,n =851).Results Blood pressure elevated with the gradually increasing Hb levels(P <0.05 ).Pearson correlation analysis showed that Hb significant positive correlated with weight,W,H,systolic blood pressure (SBP),diastolic blood pressure (DBP), ALT,triglyceride(TG),FBG and body mass index(BMI),but significant negative correlated with high density lipoprotein cholesterol(P <0.01 ).Logistic regression analysis showed that the highest quartile group of Hb in the risk of hypertension as the lowest quartile group was 2.461 times after adjusting for gender and cardiovascular disease risk factors.Multiple regression analysis showed that Hb was the inde-pendent risk factor of SBP and DBP.Conclusion For the subjects aged 60 years or above,blood pressure was elevated with the increasing Hb levels,elevated hemoglobin may be associated with the occurrence and development of hypertension.%目的：探讨老年人血红蛋白（Hb）含量与血压水平的相关性。方法以上海市闵行区江川社区2101例60岁以上体检者为研究对象。测量身高、体重、腰围（W）、臀围（H）和血压，检测 Hb、血脂、空腹血糖（FBG）、血肌酐（Cr）和丙氨酸转氨酶（ALT）。根据血压水平将其分为3组：正常血压组（＜120／80 mmHg，477例）、高血压前期组（120～139／80～89 mmHg，773例）、高血压组（≥140／90 mmHg，851例）。结果随着 Hb 含量逐渐升高，血压水平随之升高（P ＜0．05）。Pearson 相关分析显示，Hb 含量与体重、W、H、收缩压（SBP）、舒张压（DBP）、ALT、甘油三酯（TG）、FBG 及体重指数（BMI）均呈显著正相关，与高密度脂蛋白胆固醇呈显著负相关（P ＜0．01）。Logistic回归分析结果显示，在校正性别及心血管疾病危险因素后，Hb 最高四分位组发生高血压的危险性是最低四分位组的2．461倍（P ＜0．01）。多元逐步回归结果显示，Hb 是 SBP 和 DBP 升高的独立危险因素（P ＜0．01）。结论老年人群中随着 Hb 含量升高其血压水平随之升高，Hb 含量升高可能与高血压的发生及发展有关。