目的 观察内生场腹腔热灌注化疗治疗晚期原发性肝癌患者的安全性和疗效.方法 对42例晚期原发性肝癌患者进行以顺铂联合氟尿嘧啶为主的内生场腹腔热灌注化疗,观察化疗前后的效果.另39例原发性肝癌给予一般支持治疗.结果 经腹腔热灌注化疗,总有效率(RR)59.5%,腹水控制率81%.两组差异有统计学意义.治疗组和对照组中位生存期分别为17个月和3个月,差异有统计学意义(P<0.05).治疗组和对照组累计生存率比较差异有统计学意义(P<0.05).副作用主要为乏力、出汗.结论 内生场腹腔热灌注化疗对晚期原发性肝癌有较好的控制,且安全性好.%Objective To observe the effects and adverse reactions of continuous hyperthermic peritoneal perfusion chemotherapy with endogenefic field tumor hyperthemic system in the treatment of 81 patients with primary hepatic carcinoma. Methods 42 patients with primary hepatic carcinoma were treated with DDP and 5-FU by CHPPC and 39 patients were treated with support therapy. Results The overall response rate of the CHPPC was 59.5％ and the complete remission rate of ascites was 81％. There was a significant difference between the two groups (P＜0.05). The median survival time of the treatment group and the control group were 17 months and 3 months respectively; there was a significant difference between the two groups (P＜0.05). The cumulative survival rate was significantly different betwveen the treatment group and the control group(P＜0.05). The main side effects were fatigue and sweatiness. Conclusion CHPPC with endogenetic field tumor hyperthemic systen for advanced primary hepatic carcinoma is safe and feasible.
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